ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2013
Impact of age on myocardial uptake of ¹²³I-mIBG in older adult subjects without coronary heart disease.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
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- What does diagnostic threshold mean? Deterministic and probabilistic considerations.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- CardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Incremental prognostic value of myocardial neuroadrenergic damage in patients with chronic congestive heart failure: An iodine-123 meta-iodobenzylguanidine scintigraphy study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
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- A Comparative Assessment of Cardiovascular Autonomic Reflex Testing and CardiacInternational journal of endocrinology · 2018Article
- Assessment ofJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Iodine-123 metaiodobenzylguanidine scintigraphy for the assessment of cardiac sympathetic innervation and the relationship with cardiac autonomic function in healthy adults using standardized methods.Nuclear medicine communications · 2017Article
- Impact of aging on cardiac sympathetic innervation measured byEuropean journal of nuclear medicine and molecular imaging · 2016Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to examine the relationship between myocardial uptake of (123)I-mIBG and age in older normal adult subjects.
methods94 subjects (age 29-82, mean 58.5) without coronary heart disease were studied. All subjects underwent early and delayed planar and 4-hour SPECT (123)I-mIBG imaging. (123)I-mIBG uptake was quantified as heart/mediastinum ratio on planar images (H/M p) and on SPECT images (H/M s) reconstructed by filtered backprojection, ordered subsets-expectation maximization (OSEM), and OSEM with compensation for collimator septal penetration (DSP). Relationships between age and (123)I-mIBG uptake were examined by correlation analysis, t-tests, and analysis of variance.
resultsThere was no significant correlation between age and H/M p, reflecting comparable increases in activity in the two regions of interest with age. Results on SPECT analyses were comparable, with no significant correlation between age and H/M s. Using DSP, (123)I-mIBG H/M s was significantly higher in subjects ≥70 of age compared with younger subjects.
conclusionsBoth cardiac and background uptake of (123)I-mIBG increase with age in older subjects without coronary heart disease, resulting in stability of H/M results (planar and SPECT). This study suggests that prognostic analyses of quantitative (123)I-mIBG uptake in patients with heart disease do not require adjustment for patient age.
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