ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2013
Elevation of tumor necrosis factor α in dorsal root ganglia and spinal cord is associated with neuroimmune modulation of pain in an animal model of multiple sclerosis.
Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis.Frontiers in molecular biosciences · 2025Article
- Caveolin-1 knockout improves CFA-induced inflammatory pain in adult mice through modulating the cGAS STING pathway and autophagy.PloS one · 2025Article
- Mirtazapine Improves Locomotor Activity and Attenuates Neuropathic Pain Following Spinal Cord Injury in Rats via Neuroinflammation Modulation.Neurochemical research · 2024Article
- Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders.Cellular and molecular neurobiology · 2023Review
- Dangerous Behavior and Intractable Axial Skeletal Pain in Performance Horses: A Possible Role for Ganglioneuritis (14 Cases; 2014-2019).Frontiers in veterinary science · 2021Article
- Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation.Journal of neuroinflammation · 2018Article
- Article
- Expression and Differential Responsiveness of Central Nervous System Glial Cell Populations to the Acute Phase Protein Serum Amyloid A.Scientific reports · 2017Article
- Experimental Autoimmune Encephalomyelitis (EAE)-Induced Elevated Expression of the E1 Isoform of Methyl CpG Binding Protein 2 (MeCP2E1): Implications in Multiple Sclerosis (MS)-Induced Neurological Disability and Associated Myelin Damage.International journal of molecular sciences · 2017Article
- Peripheral sensory neuron injury contributes to neuropathic pain in experimental autoimmune encephalomyelitis.Scientific reports · 2017Article
- IL-1β Is Involved with the Generation of Pain in Experimental Autoimmune Encephalomyelitis.Molecular neurobiology · 2016Article
- Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE.Experimental neurology · 2016Article
- Transcriptional Regulation of Brain-Derived Neurotrophic Factor (BDNF) by Methyl CpG Binding Protein 2 (MeCP2): a Novel Mechanism for Re-Myelination and/or Myelin Repair Involved in the Treatment of Multiple Sclerosis (MS).Molecular neurobiology · 2016Review
- Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis.Journal of neuroinflammation · 2016Article
- Peripheral and Central Neuroinflammatory Changes and Pain Behaviors in an Animal Model of Multiple Sclerosis.Frontiers in immunology · 2016Article
- Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models.Inflammopharmacology · 2014Review
- Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain.BioMed research international · 2013Article
- Neuropathic pain in animal models of nervous system autoimmune diseases.Mediators of inflammation · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathic pain (NPP) is a frequently reported symptom described by 50-80% of multiple sclerosis (MS) patients. Although Th1 cell activation is known to drive the pathology of MS, this critical step has also been suggested to be involved in the neuroimmune induction of NPP. The release of pain inducing inflammatory cytokines such as tumour necrosis factor alpha (TNFα) from activated Th1 cells may have key implications in the development of MS-induced pain. We hypothesize that immune mediated antigenic induction of inflammatory cytokines such as TNFα within dorsal root ganglia (DRG) and spinal cord (SC) facilitate the cellular events underlying induction of pain. A rat experimental autoimmune encephalomyelitis (EAE) model of MS was utilized to identify the cellular source and expression changes of TNFα protein and mRNA in the DRG and SC. The TNFα levels in the DRG and SC were correlated with the behavioral testing indicative of NPP. We show significant increases in TNFα protein and mRNA expression in DRG and SC of EAE animals at 12 days post induction (EAE12) relative to naïve control (NC) and active control (AC) groups. Further, we show increased TNFα protein and mRNA expression at the dorsal root entry point, which suggests the anterograde transport of both protein and mRNA. Further, the onset of NPP coincides with increased TNFα expression in the SC. These results demonstrate that the elevated expression of TNFα in the DRG and SC may be associated with the pathological induction of NPP in an animal model of MS.
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