ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2013
Congenital idiopathic hydrocephalus of infancy: the results of treatment by endoscopic third ventriculostomy with or without choroid plexus cauterization and suggestions for how it works.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Efficacy and safety of endoscopic third ventriculostomy and choroid plexus cauterization for infantile hydrocephalus: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Pooled it
- Endoscopic third ventriculostomy with/without choroid plexus cauterization for hydrocephalus due to hemorrhage, infection, Dandy-Walker malformation, and neural tube defect: a meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Pooled it
- Five-year outcomes after surgical treatment of infant postinfectious hydrocephalus in sub-Saharan Africa: results of a randomized trial.Journal of neurosurgery. Pediatrics · 2025Trial
- Endoscopic Treatment versus Shunting for Infant Hydrocephalus in Uganda.The New England journal of medicine · 2017Trial
- Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review.Fluids and barriers of the CNS · 2026Review
- Intraoperative effects of ETV and CPC on intraventricular pressure and pulsation amplitude: A preliminary investigation of the hydrodynamic model of infant hydrocephalus.medRxiv : the preprint server for health sciences · 2026Article
- Cerebrospinal fluid volume outperforms traditional measures for predicting treatment failure in infant hydrocephalus.Fluids and barriers of the CNS · 2026Article
- Understanding barriers to pediatric hydrocephalus management: an international survey.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Treatment failure after endoscopic third ventriculostomy with choroid plexus cauterization, endoscopic third ventriculostomy alone, and ventriculoperitoneal shunt in congenital hydrocephalus: a network and time-to-event meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Endoscopic Third Ventriculostomy with Choroid Plexus Coagulation for Infant Hydrocephalus.Advances and technical standards in neurosurgery · 2026Review
- Endoscopic third ventriculostomy with or without choroid plexus cauterization for preventing shunt dependence in pediatric hydrocephalus: preliminary results of a prospective clinical case series in a lower-middle-income country (Egypt).Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Low surgical weight associated with ETV failure in pediatric hydrocephalus patients.Neurosurgical review · 2024Article
- Preliminary Experience Suggests the Addition of Choroid Plexus Cauterization to Functional Hemispherectomy May Reduce Posthemispherectomy Hydrocephalus.Neurosurgery · 2023Article
- Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.Fluids and barriers of the CNS · 2022Article
- Endoscopic third ventriculostomy in children with chronic communicating congenital hydrocephalus: a single-center cohort retrospective analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Article
- Endoscopic third ventriculostomy and choroid plexus cauterization (ETV/CPC) for hydrocephalus of infancy: a technical review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Endoscopic third ventriculostomy and cerebrospinal fluid shunting for pure communicating hydrocephalus in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- A Systematic Review of Neurosurgical Care in Low-Income Countries.World neurosurgery: X · 2020Review
- Hydrocephalus and mucopolysaccharidoses: what do we know and what do we not know?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe traditional bulk flow model of communicating hydrocephalus does not support treatment by endoscopic third ventriculostomy (ETV), but successful treatment is reported in adults. This study is the first to report long-term success of ETV +/- choroid plexus cauterization (CPC) for infants with congenital idiopathic hydrocephalus (CIH). The results are interpreted in the context of current models for hydrocephalus.
methodsThe CURE Children's Hospital of Uganda prospective database was reviewed for the years 2001-2006 to identify children <24 months of age meeting the criteria for CIH who underwent ETV with or without bilateral CPC. Kaplan-Meier method was used to assess treatment success survival. Gehan-Breslow-Wilcoxin and logrank tests were used to determine significance of survival differences. Fisher's exact test was used to determine the significance of differences between groups.
resultsSixty-four infants (mean/median age, 6.1/5.0 months) met the inclusion criteria. Sixteen consecutive patients were treated by ETV alone, and the subsequent 48 by ETV/CPC (mean/median follow-up 34.4/36.0 months). ETV was successful in 20 % and ETV/CPC in 72.4 % at 4 years (p < 0.0002, logrank test; p = 0.0006, Gehan-Breslow-Wilcoxin; hazard ratio 6.9, 95 % CI 2.5-19.3).
conclusionsETV/CPC was significantly more successful than ETV alone in treating CIH. The primary effect of ETV, as a pulsation absorber, and of CPC, as a pulsation reducer, may be to abate the net force of intraventricular pulsations that produce ventricular expansion. ETV alone may be less successful for infants because of greater brain compliance. ETV/CPC should be considered an effective primary treatment option.
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