ReviewMolecules and cells2013
Orai1-NFAT signalling pathway triggered by T cell receptor stimulation.
Review in Molecules and cells, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 96 citations in OpenAlex.
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- Metal Ions Within the Neuro-Immune-Tumor Axis.Journal of immunology research · 2026Review
- lncRNA signature mediates mitochondrial permeability transition-driven necrosis in regulating the tumor immune microenvironment of cervical cancer.Scientific reports · 2024Article
- A Model for the Coexistence of Competing Mechanisms forBulletin of mathematical biology · 2024Article
- Synthetic Biology Meets CaCells · 2024Review
- Multifaceted control of T cell differentiation by STIM1.Trends in biochemical sciences · 2023Review
- A multiple-oscillator mechanism underlies antigen-induced CaThe Journal of biological chemistry · 2023Article
- Orai inhibition modulates pulmonary ILC2 metabolism and alleviates airway hyperreactivity in murine and humanized models.Nature communications · 2023Article
- Too much of a good thing: The case of SOCE in cellular apoptosis.Cell calcium · 2023Review
- Super resolution microscopy analysis reveals increased Orai1 activity in asthma and cystic fibrosis lungs.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2023Article
- Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation.Frontiers in immunology · 2023Article
- CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.Cancers · 2022Review
- Orai1 overexpression improves sepsis-induced T-lymphocyte immunosuppression and acute organ dysfunction in mice.Heliyon · 2022Article
- Combination therapy of insulin-like growth factor I and BTP-2 markedly improves lipopolysaccharide-induced liver injury in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- The CaPharmaceutics · 2022Article
- CaJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- Expression of Orai1 and STIM1 in human oral squamous cell carcinogenesis.Journal of dental sciences · 2022Article
- ORAI1 Limits SARS-CoV-2 Infection by Regulating Tonic Type I IFN Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids.Function (Oxford, England) · 2022Article
- Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
T cell receptor (TCR) stimulation plays a crucial role in development, homeostasis, proliferation, cell death, cytokine production, and differentiation of T cells. Thus, in depth understanding of TCR signalling is crucial for development of therapy targeting inflammatory diseases, improvement of vaccination efficiency, and cancer therapy utilizing T cell-based strategies. TCR activation turns on various signalling pathways, one of the important one being the Ca(2+)-calcineurin-nuclear factor of activated T cells (NFAT) signalling pathway. Stimulation of TCRs triggers depletion of intracellular Ca(2+) store and in turn, initiates store-operated Ca(2+) entry (SOCE), one of the major mechanisms to raise the intracellular Ca(2+) concentrations in T cells. Ca(2+)-release-activated-Ca(2+) (CRAC) channels are a prototype of store-operated Ca(2+) (SOC) channels in immune cells that are very well characterized. Recent identification of STIM1 as the endoplasmic reticulum (ER) Ca(2+) sensor and Orai1 as the pore subunit has dramatically advanced the understanding of CRAC channels and provides a molecular tool to investigate the physiological outcomes of Ca(2+) signalling during immune responses. In this review, we focus on our current understanding of CRAC channel activation, regulation, and downstream calcineurin-NFAT signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.