ArticleCancer prevention research (Philadelphia, Pa.)2013
Is lycopene an effective agent for preventing prostate cancer?
Article in Cancer prevention research (Philadelphia, Pa.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Increased dietary and circulating lycopene are associated with reduced prostate cancer risk: a systematic review and meta-analysis.Prostate cancer and prostatic diseases · 2017Pooled it
- Genome-Wide Analysis of Fruit Color and Carotenoid Content inPlants (Basel, Switzerland) · 2024Article
- Pigment Biosynthesis and Molecular Genetics of Fruit Color in Pepper.Plants (Basel, Switzerland) · 2023Review
- β-Carotene 9',10' Oxygenase Modulates the Anticancer Activity of Dietary Tomato or Lycopene on Prostate Carcinogenesis in the TRAMP Model.Cancer prevention research (Philadelphia, Pa.) · 2017Article
- Broccoli-Derived Sulforaphane and Chemoprevention of Prostate Cancer: From Bench to Bedside.Current pharmacology reports · 2015Article
- Food Processing and the Mediterranean Diet.Nutrients · 2015Review
- Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Enhancing the health-promoting effects of tomato fruit for biofortified food.Mediators of inflammation · 2014Review
- Future directions in the prevention of prostate cancer.Nature reviews. Clinical oncology · 2014Review
- Biochemistry and molecular biology of carotenoid biosynthesis in chili peppers (Capsicum spp.).International journal of molecular sciences · 2013Review
- The potential role of lycopene for the prevention and therapy of prostate cancer: from molecular mechanisms to clinical evidence.International journal of molecular sciences · 2013Review
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of lycopene, an open-chain carotenoid found in tomatoes and devoid of retinoid activity, as an anticarcinogenic, chemopreventive agent, especially for use in prostate cancer, is still under active investigation. In this issue, Qui and colleagues show that lycopene induces responses in human prostate epithelial cells that are antiproliferative, antioxidative, and anti-inflammatory, as well as downregulating targets in the androgen receptor signaling pathway. In this perspective, we review aspects of the molecular and cellular biology of lycopene that support its use for prevention of prostate cancer. Whether lycopene itself or its metabolites induce most of its benefits is still uncertain. At present, meta-analysis of clinical studies of lycopene for prevention of prostate cancer in men does not yet support the definitive clinical use of this carotenoid in a preventive setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.