Establishing the role of tyrosine kinase 2 in cancer.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

1. TYK2 Variants in B-Acute Lymphoblastic Leukaemia.Genes · 2020
   Trial
2. Flavonoid-modulated JAK-STAT signaling mitigates malignant transformation and drug resistance in breast tumors: A clinically relevant 3PM-guided innovation.Journal of advanced research · 2026
   Review
3. From Lab to Clinic: How Artificial Intelligence (AI) Is Reshaping Drug Discovery Timelines and Industry Outcomes.Pharmaceuticals (Basel, Switzerland) · 2025
   Review
4. Targeting TYK2 for Fighting Diseases: Recent Advance of TYK2 Inhibitors.Current medicinal chemistry · 2024
   Review
5. The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.Journal of cancer research and clinical oncology · 2023
   Article
6. The expression and the tumor suppressor role of CLDN6 in colon cancer.Molecular and cellular biochemistry · 2022
   Article
7. IL22RA1/JAK/STAT Signaling Acts As a Cancer Target Through Pan-Cancer Analysis.Frontiers in immunology · 2022
   Article
8. TYK2 correlates with immune infiltration: A prognostic marker for head and neck squamous cell carcinoma.Frontiers in genetics · 2022
   Article
9. Prognostic values and clinical relationship of TYK2 in laryngeal squamous cell cancer.Medicine · 2021
   Observational
10. TYK2 in Cancer Metastases: Genomic and Proteomic Discovery.Cancers · 2021
    Review
11. Activation of Interferon Signaling in Chronic Lymphocytic Leukemia Cells Contributes to Apoptosis Resistance via a JAK-Src/STAT3/Mcl-1 Signaling Pathway.Biomedicines · 2021
    Article
12. SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women.Oncotarget · 2020
    Article
13. Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib.The oncologist · 2020
    Review
14. TYK2 in Tumor Immunosurveillance.Cancers · 2020
    Review
15. TYK2: An Upstream Kinase of STATs in Cancer.Cancers · 2019
    Review
16. Blockade of ACK1/TNK2 To Squelch the Survival of Prostate Cancer Stem-like Cells.Scientific reports · 2018
    Article
17. Cancer Transcriptome Dataset Analysis: Comparing Methods of Pathway and Gene Regulatory Network-Based Cluster Identification.Omics : a journal of integrative biology · 2017
    Article
18. Oncoimmunology · 2015
    Article
19. Uncovering potential downstream targets of oncogenic GRPR overexpression in prostate carcinomas harboring ETS rearrangements.Oncoscience · 2015
    Article
20. Role of Tyk-2 in Th9 and Th17 cells in allergic asthma.Scientific reports · 2014
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

5 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

Indexed as