ArticleIranian Red Crescent medical journal2012
Comparison between presence of epstein barr virus in nodal and extra nodal diffuse large B cell lymphoma of head and neck, an Iranian experience.
Article in Iranian Red Crescent medical journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Molecular Epidemiology of Epstein-Barr virus (EBV) in Patients with Hematologic Malignancies.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Clinicopathological and Immunohistochemical Study of Head and Neck Langerhans Cell Histiocytosis from Latin America.Head and neck pathology · 2018Article
- Evidence of EBV infection in lymphomas diagnosed in Lusaka, Zambia.The Pan African medical journal · 2018Article
- Extranodal NK/T Cell Lymphoma with Destruction of the Uvulae: A Case Report.Iranian journal of otorhinolaryngology · 2017Article
- Detection of Epstein-Barr Virus DNA in Langerhans Cell Histiocytosis.Jundishapur journal of microbiology · 2015Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
backgroundEpstein Barr Virus (EBV) is one of the most common viral infections in human population. EBV has a significant role in pathogenesis of Hodgkin's lymphoma, Burkitt's lymphoma and nasopharyngeal carcinoma. The role of EBV in non-Hodgkin's lymphoma, diffuse large B cell (NHL - DLBL) in the head and neck is controversial.
objectivesThe purpose of this study is to find out the difference between the presence of Epstein Barr virus in nodal and extra nodal lymphoma of head and neck. PATIENTS AND
methodsA total of 30 cases of DLBL in two separate groups were collected from pathology department. The first group was consisted of 15 patients with DLBL of neck lymph node and the other was consisted of 15 patients with extra nodal DLBL of head and neck mainly in palatine tonsil. Both immune-histo-chemical (IHC) study and polymerase chain reaction (PCR) for detection of late membrane antigen (LMP) were performed on formalin fixed paraffin embedded tissue.
resultsAll 30 cases were negative for EBV in IHC method. But in PCR method, 10% of patients were positive for LMP gene. There were 2 positive cases in nodal lymphoma and 1 positive case in extra nodal lymphoma group.
conclusionsCompare with PCR method, it seems that IHC is not a sensitive method for detection of EBV. Overall, the finding of EBV in NHL depends on site, type of lymphoma and the detection method.
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