Evidence map›Paper›PMID 23482877›Full record

ArticleMobile genetic elements2012

Various pathways leading to the acquisition of antibiotic resistance by natural transformation.

Sara Domingues, Kaare M Nielsen, Gabriela J da Silva

Abstract read
In one paragraph

Article in Mobile genetic elements, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Rethinking One Health: Microbial Foundations for Ecological Governance.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Review
  4. Article
  5. Novel Selectable Marker Sesquiterpenoid Antibiotic Pentalenolactone.International journal of molecular sciences · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Antimicrobial Resistance in ESKAPE Pathogens.Clinical microbiology reviews · 2020
    Review
  13. Article
  14. MCR-1 Gene Encoded Colistin-ResistantInternational journal of microbiology · 2020
    Article
  15. The Growing Threat of Antibiotic Resistance in Children.Infectious disease clinics of North America · 2018
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sara DominguesCentre of Pharmaceutical Studies; Faculty of Pharmacy; University of Coimbra; Coimbra, Portugal ; Department of Pharmacy; Faculty of Health Sciences; University of Tromsø; Tromsø, Norway.
Kaare M Nielsen
Gabriela J da Silva

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural transformation can lead to exchange of DNA between taxonomically diverse bacteria. In the case of chromosomal DNA, homology-based recombination with the recipient genome is usually necessary for heritable stability. In our recent study, we have shown that natural transformation can promote the transfer of transposons, IS elements, and integrons and gene cassettes, largely independent of the genetic relationship between the donor and recipient bacteria. Additional results from our study suggest that natural transformation with species-foreign DNA might result in the uptake of a wide range of DNA fragments; leading to changes in the antimicrobial susceptibility profile and contributing to the generation of antimicrobial resistance in bacteria.

Indexed as

Acinetobacterclass 1 integronsgene cassetteshomologous recombinationmosaic genesnatural transformationtranspositiontransposons

Identifiers

PMID23482877
PMCPMC3575418

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.