ArticlePlant physiology2013
Reduction of oxalate levels in tomato fruit and consequent metabolic remodeling following overexpression of a fungal oxalate decarboxylase.
Article in Plant physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 75 citations in OpenAlex.
- Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity inVirulence · 2025Article
- Functional diversification of oxalate decarboxylases in terms of enzymatic activity, morphosporogenesis, stress regulation and virulence inFrontiers in microbiology · 2025Article
- Oxalate and oxalotrophy: an environmental perspective.Sustainable microbiology · 2024Review
- Dynamic Change of Carbon and Nitrogen Sources in Colonized Apples byFoods (Basel, Switzerland) · 2022Article
- Tomatoes: An Extensive Review of the Associated Health Impacts of Tomatoes and Factors That Can Affect Their Cultivation.Biology · 2022Review
- Genetic manipulation of anti-nutritional factors in major crops for a sustainable diet in future.Frontiers in plant science · 2022Review
- Tomato Oxalyl-CoA Synthetase Degrades Oxalate and Affects Fruit Quality.Frontiers in plant science · 2022Article
- Regulation of Oxalate Metabolism in Spinach Revealed by RNA-Seq-Based Transcriptomic Analysis.International journal of molecular sciences · 2021Article
- An Arabidopsis Oxalyl-CoA Decarboxylase, AtOXC, Is Important for Oxalate Catabolism in Plants.International journal of molecular sciences · 2021Article
- Microbial Community and Function-Based Synthetic Bioinoculants: A Perspective for Sustainable Agriculture.Frontiers in microbiology · 2021Review
- Nutrient and Sensory Metabolites Profiling ofMolecules (Basel, Switzerland) · 2020Article
- Impacts of plant growth promoters and plant growth regulators on rainfed agriculture.PloS one · 2020Article
- An overview on improvement of crop productivity in saline soils by halotolerant and halophilic PGPRs.3 Biotech · 2019Review
- Grey mould of strawberry, a devastating disease caused by the ubiquitous necrotrophic fungal pathogen Botrytis cinerea.Molecular plant pathology · 2019Review
- Sensory quality and flavour of alginate coated and repetitive pulsed light treated fresh-cut cantaloupes (Journal of food science and technology · 2019Article
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions.PloS one · 2019Article
- Expression Analysis of Oxalate Metabolic Pathway Genes Reveals Oxalate Regulation Patterns in Spinach.Molecules (Basel, Switzerland) · 2018Article
- Recovering Tomato Landraces to Simultaneously Improve Fruit Yield and Nutritional Quality Against Salt Stress.Frontiers in plant science · 2018Article
- In vitro and in vivo safety evaluation of Nephure™.Regulatory toxicology and pharmacology : RTP · 2017Article
- Chickpea transcription factor CaTLP1 interacts with protein kinases, modulates ROS accumulation and promotes ABA-mediated stomatal closure.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant metabolite oxalic acid is increasingly recognized as a food toxin with negative effects on human nutrition. Decarboxylative degradation of oxalic acid is catalyzed, in a substrate-specific reaction, by oxalate decarboxylase (OXDC), forming formic acid and carbon dioxide. Attempts to date to reduce oxalic acid levels and to understand the biological significance of OXDC in crop plants have met with little success. To investigate the role of OXDC and the metabolic consequences of oxalate down-regulation in a heterotrophic, oxalic acid-accumulating fruit, we generated transgenic tomato (Solanum lycopersicum) plants expressing an OXDC (FvOXDC) from the fungus Flammulina velutipes specifically in the fruit. These E8.2-OXDC fruit showed up to a 90% reduction in oxalate content, which correlated with concomitant increases in calcium, iron, and citrate. Expression of OXDC affected neither carbon dioxide assimilation rates nor resulted in any detectable morphological differences in the transgenic plants. Comparative proteomic analysis suggested that metabolic remodeling was associated with the decrease in oxalate content in transgenic fruit. Examination of the E8.2-OXDC fruit proteome revealed that OXDC-responsive proteins involved in metabolism and stress responses represented the most substantially up- and down-regulated categories, respectively, in the transgenic fruit, compared with those of wild-type plants. Collectively, our study provides insights into OXDC-regulated metabolic networks and may provide a widely applicable strategy for enhancing crop nutritional value.
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