ArticleThe Plant cell2013
An RNA virus-encoded zinc-finger protein acts as a plant transcription factor and induces a regulator of cell size and proliferation in two tobacco species.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- The role of cysteine-rich protein in enhancing mandarivirus infectivity and pathogenicity.Journal of virology · 2025Article
- Discovery and characterization of a novel carlavirus in Ligularia jaluensis plants.Virologica Sinica · 2025Article
- Characterization of mint virus C, a new member of the genus Carlavirus.Archives of virology · 2025Article
- Meta-Transcriptomic Analysis Uncovers the Presence of Four Novel Viruses and Multiple Known Virus Genera in a SingleViruses · 2024Article
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- Identification of a novel viral factor inducing tumorous symptoms by disturbing vascular developmentJournal of virology · 2023Article
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- A Zinc Finger Motif in the P1 N Terminus, Highly Conserved in a Subset of Potyviruses, Is Associated with the Host Range and Fitness of Telosma Mosaic Virus.Journal of virology · 2023Article
- Article
- Virome ofFrontiers in microbiology · 2022Article
- Effect of RNA silencing suppression activity of chrysanthemum virus B p12 protein on small RNA species.Archives of virology · 2020Article
- A distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1.Science advances · 2020Article
- Chimeric Tobamoviruses With Coat Protein Exchanges Modulate Symptom Expression and Defence Responses inFrontiers in microbiology · 2020Article
- Massive up-regulation of LBD transcription factors and EXPANSINs highlights the regulatory programs of rhizomania disease.Molecular plant pathology · 2018Article
- N-terminal region of cysteine-rich protein (CRP) in carlaviruses is involved in the determination of symptom types.Molecular plant pathology · 2018Article
- The coat protein of Alfalfa mosaic virus interacts and interferes with the transcriptional activity of the bHLH transcription factor ILR3 promoting salicylic acid-dependent defence signalling response.Molecular plant pathology · 2017Article
- A petunia ethylene-responsive element binding factor, PhERF2, plays an important role in antiviral RNA silencing.Journal of experimental botany · 2016Article
- Overexpression of SlUPA-like induces cell enlargement, aberrant development and low stress tolerance through phytohormonal pathway in tomato.Scientific reports · 2016Article
- Symptoms induced by transgenic expression of p23 from Citrus tristeza virus in phloem-associated cells of Mexican lime mimic virus infection without the aberrations accompanying constitutive expression.Molecular plant pathology · 2015Article
- A critical domain of Sweet potato chlorotic fleck virus nucleotide-binding protein (NaBp) for RNA silencing suppression, nuclear localization and viral pathogenesis.Molecular plant pathology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant viruses cause a variety of diseases in susceptible hosts. The disease symptoms often include leaf malformations and other developmental abnormalities, suggesting that viruses can affect plant development. However, little is known about the mechanisms underlying virus interference with plant morphogenesis. Here, we show that a C-4 type zinc-finger (ZF) protein, p12, encoded by a carlavirus (chrysanthemum virus B) can induce cell proliferation, which results in hyperplasia and severe leaf malformation. We demonstrate that the p12 protein activates expression of a regulator of cell size and proliferation, designated upp-L (upregulated by p12), which encodes a transcription factor of the basic/helix-loop-helix family sufficient to cause hyperplasia. The induction of upp-L requires translocation of the p12 protein into the nucleus and ZF-dependent specific interaction with the conserved regulatory region in the upp-L promoter. Our results establish the role of the p12 protein in modulation of host cell morphogenesis. It is likely that other members of the conserved C-4 type ZF family of viral proteins instigate reprogramming of plant development by mimicking eukaryotic transcriptional activators.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.