ArticleThe Journal of endocrinology2013
Intrauterine growth restriction alters term fetal baboon hypothalamic appetitive peptide balance.
Article in The Journal of endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
- Moderate maternal nutrient restriction alters type II alveolar epithelial cell density in the non-human primate fetal lung.Experimental physiology · 2026Article
- Maternal Nutritional Environment and the Development of the Melanocortin System.Comprehensive Physiology · 2025Review
- Maternal under-nutrition during pregnancy alters the molecular response to over-nutrition in multiple organs and tissues in nonhuman primate juvenile offspring.Journal of developmental origins of health and disease · 2024Article
- Unraveling the Molecular Mechanisms of the Neurodevelopmental Consequences of Fetal Protein Deficiency: Insights From Rodent Models and Public Health Implications.Biological psychiatry global open science · 2024Review
- Fetal origins of obesity: a novel pathway of regulating appetite neurons in the hypothalamus of growth-restricted rat offspring.Archives of gynecology and obstetrics · 2024Article
- Perinatal maternal undernutrition in baboons modulates hepatic mitochondrial function but not metabolites in aging offspring.bioRxiv : the preprint server for biology · 2024Article
- Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model.International journal of molecular sciences · 2023Article
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- Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction.Clinical science (London, England : 1979) · 2021Article
- Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors.Science advances · 2021Article
- The nonhuman primate hypothalamo-pituitary-adrenal axis is an orchestrator of programming-aging interactions: role of nutrition.Nutrition reviews · 2020Review
- Metabolic regulation of kisspeptin - the link between energy balance and reproduction.Nature reviews. Endocrinology · 2020Review
- Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work.Journal of developmental origins of health and disease · 2020Review
- High Branched-Chain Amino Acid Concentrations Are Found in Preterm Baboons Receiving Intravenous Amino Acid Solutions and Mimic Alterations Found in Preterm Infants.JPEN. Journal of parenteral and enteral nutrition · 2019Article
- Ontogeny and programming of the fetal temporal cortical endocannabinoid system by moderate maternal nutrient reduction in baboons (Papio spp.).Physiological reports · 2019Article
- Reproductive cycling in adult baboons (Papio species) that were intrauterine growth restricted at birth implies normal fertility but increased psychosocial stress.Journal of medical primatology · 2018Article
- Birth weight and catch up growth are associated with childhood impulsivity in two independent cohorts.Scientific reports · 2018Article
- Article
- Nonhuman primate breath volatile organic compounds associate with developmental programming and cardio-metabolic status.Journal of breath research · 2018Article
- Maternal activity, anxiety, and protectiveness during moderate nutrient restriction in captive baboons (Papio sp.).Journal of medical primatology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Neurons controlling appetite are located in the hypothalamic arcuate nuclei (ARH). Offspring appetite regulation has been shown to be modified by dysregulation of ARH nuclear development. Most ARH developmental studies have been in altricial rodents whose hypothalamic development is predominantly postnatal. In primates including humans, much development of hypothalamic appetite regulatory centers occurs before birth. We hypothesized that i) appetitive peptides are abundantly expressed by 90 percent gestation (0.9G), ready for postnatal function; ii) by 0.9G, intrauterine growth restriction (IUGR) increases the orexigenic:anorexigenic peptide ratio; iii) IUGR increases fetal glucocorticoid receptor (GR) expression; and iv) IUGR decreases STAT3, which signals inhibition of appetite. We developed a fetal baboon IUGR model resulting from reduced maternal nutrition. Pregnant baboons were fed ad libitum, controls (CTR; n=24), or 70% CTR diet to produce IUGR (n=14). C-section was performed at 0.9G. In CTR (n=7) and IUGR (n=6) fetal brains, ARH appetite regulatory peptides (neuropeptide Y (NPY) and proopiomelanocortin (POMC)) were quantified immunohistochemically. Fetal plasma cortisol was raised in IUGR fetuses. We observed that NPY and POMC were well expressed by 0.9G. IUGR increased NPY, GR, and active phosphorylated GR and decreased POMC and phosphorylated form of STAT3. We conclude that IUGR dysregulates ARH development in ways that will reset the appetitive neuropeptide balance in favor of increased appetite drive in postnatal life. We postulate that changes in peptide abundance are in part due to increased fetal cortisol and ARH GR. These changes may contribute to predisposition to obesity in IUGR offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.