ArticleScience signaling2013
The emergence of the conserved AAA+ ATPases Pontin and Reptin on the signaling landscape.
Article in Science signaling, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 56 citations in OpenAlex.
- The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors.Nature communications · 2022Article
- Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFβ/SMAD signalling during gliomagenesis.Cell death & disease · 2022Article
- Pontin Functions as A Transcriptional Co-activator for Retinoic Acid-induced HOX Gene Expression.Journal of molecular biology · 2021Article
- AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors.European journal of medicinal chemistry · 2021Review
- Targeted deletion of Ruvbl1 results in severe defects of epidermal development and perinatal mortality.Molecular and cellular pediatrics · 2021Article
- Pontin arginine methylation by CARM1 is crucial for epigenetic regulation of autophagy.Nature communications · 2020Article
- Exaptive Evolution of Target of Rapamycin Signaling in Multicellular Eukaryotes.Developmental cell · 2020Review
- Article
- Synthetic lethality by targeting the RUVBL1/2-TTT complex in mTORC1-hyperactive cancer cells.Science advances · 2020Article
- TOR dynamically regulates plant cell-cell transport.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Telomerase and Telomeres in Endometrial Cancer.Frontiers in oncology · 2019Review
- Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma.Cancer cell international · 2019Article
- X-ray structure of full-length human RuvB-Like 2 - mechanistic insights into coupling between ATP binding and mechanical action.Scientific reports · 2018Article
- Plasmodium falciparum RUVBL3 protein: a novel DNA modifying enzyme and an interacting partner of essential HAT protein MYST.Scientific reports · 2018Article
- Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.Experimental & molecular medicine · 2018Article
- The Sequence-specific Peptide-binding Activity of the Protein Sulfide Isomerase AGR2 Directs Its Stable Binding to the Oncogenic Receptor EpCAM.Molecular & cellular proteomics : MCP · 2018Article
- DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.Human molecular genetics · 2018Article
- Complexes formed by mutant p53 and their roles in breast cancer.Breast cancer (Dove Medical Press) · 2018Review
- Article
- Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 6 countries.
Funding
Abstract
Pontin (also known as RUVBL1 and RVB1) and Reptin (also called RUVBL2 and RVB2) are related members of the large AAA+ (adenosine triphosphatase associated with diverse cellular activities) superfamily of conserved proteins. Various cellular functions depend on Pontin and Reptin, mostly because of their functions in the assembly of protein complexes that play a role in the regulation of cellular energetic metabolism, transcription, chromatin remodeling, and the DNA damage response. Little is known, though, about the interconnections between these multiple functions, how the relevant signaling pathways are regulated, whether the interconnections are affected in human disease, and whether components of these pathways are suitable targets for therapeutic intervention. The First International Workshop on Pontin (RUVBL1) and Reptin (RUVBL2), held between 16 and 19 October 2012, discussed the nature of the oligomeric organization of these proteins, their structures, their roles as partners in various protein complexes, and their involvement in cellular regulation, signaling, and pathophysiology, as well as their potential for therapeutic targeting. A major outcome of the meeting was a general consensus that most functions of Pontin and Reptin are related to their roles as chaperones or adaptor proteins that are important for the assembly and function of large signaling protein complexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.