ArticleKorean journal of pediatrics2013
Bone mineral density deficits in childhood cancer survivors: Pathophysiology, prevalence, screening, and management.
Article in Korean journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Aggravated bone density decline following symptomatic osteonecrosis in children with acute lymphoblastic leukemia.Haematologica · 2015Trial
- Radiomorphometric indices and bone findings on panoramic images of childhood cancer survivors.Imaging science in dentistry · 2025Article
- Factors affecting bone mineral density in children and adolescents with secondary osteoporosis.Annals of pediatric endocrinology & metabolism · 2023Article
- Individual Trajectories of Bone Mineral Density Reveal Persistent Bone Loss in Bone Sarcoma Patients: A Retrospective Study.Journal of clinical medicine · 2022Article
- Osteoporosis in Childhood Cancer Survivors: Physiopathology, Prevention, Therapy and Future Perspectives.Cancers · 2022Review
- [Endocrine late-effects and bone mineral density after combined treatment of malignant brain tumors in childhood and adolescence].Problemy endokrinologii · 2021Article
- Endocrine Complications in Children and Adolescents With Non-Central Nervous System Solid Tumors.Frontiers in endocrinology · 2021Article
- Low bone mineral density is associated with hypogonadism and cranial irradiation in male childhood cancer survivors.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Bone morbidity in pediatric acute lymphoblastic leukemia.Annals of pediatric endocrinology & metabolism · 2020Article
- Mandibular radiomorphometric assessment of bone mineral density in survivors of pediatric hematopoietic stem-cell transplantation.Clinics (Sao Paulo, Brazil) · 2019Article
- Pegylated interferon α/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HCV infection.World journal of pediatrics : WJP · 2017Article
- Comparison of mandibular cortical thickness and QCT-derived bone mineral density (BMD) in survivors of childhood acute lymphoblastic leukemia: a retrospective study.International journal of paediatric dentistry · 2016Article
- Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma.Annals of pediatric endocrinology & metabolism · 2015Article
- The bone-fat interface: basic and clinical implications of marrow adiposity.The lancet. Diabetes & endocrinology · 2015Review
- Does this chest radiograph belong to a survivor of childhood cancer? Radiographic findings suggesting previous treatment for childhood cancer - a review.Journal of the American Osteopathic College of Radiology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As chemotherapy and other sophisticated treatment strategies evolve and the number of survivors of long-term childhood cancer grows, the long-term complications of treatment and the cancer itself are becoming ever more important. One of the most important but often neglected complications is osteoporosis and increased risk of fracture during and after cancer treatment. Acquisition of optimal peak bone mass and strength during childhood and adolescence is critical to preventing osteoporosis later in life. However, most childhood cancer patients have multiple risk factors for bone mineral loss. Cancer itself, malnutrition, decreased physical activity during treatment, chemotherapeutic agents such as steroids, and radiotherapy cause bone mineral deficit. Furthermore, complications such as growth hormone deficiency and musculoskeletal deformity have negative effects on bone metabolism. Low bone mineral density is associated with fractures, skeletal deformity, pain, and substantial financial burden not only for childhood cancer survivors but also for public health care systems. Thus, it is important to monitor bone health in these patients and minimize their risk of developing osteoporosis and fragility fractures later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.