ArticleSocial cognitive and affective neuroscience2014
Neural correlates of impaired emotion processing in manifest Huntington's disease.
Article in Social cognitive and affective neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural correlates of emotional prosody in Parkinson's disease: A systematic review.Cognitive, affective & behavioral neuroscience · 2026Pooled it
- Functional connectivity modeling of consistent cortico-striatal degeneration in Huntington's disease.NeuroImage. Clinical · 2015Pooled it
- Autonomic dysfunction in neurodegenerative disease.Nature reviews. Neuroscience · 2025Review
- Facial emotion recognition deficits are associated with hypomimia and related brain correlates in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- Article
- Problems with Social Cognition and Decision-Making in Huntington's Disease: Why Is it Important?Brain sciences · 2021Review
- Abnormal visual scanning and impaired mental state recognition in pre-manifest Huntington disease.Experimental brain research · 2021Article
- Through your eyes or mine? The neural correlates of mental state recognition in Huntington's disease.Human brain mapping · 2018Article
- Impaired Recognition of Emotional Faces after Stroke Involving Right Amygdala or Insula.Seminars in speech and language · 2018Review
- The Alteration of Emotion Regulation Precedes the Deficits in Interval Timing in the BACHD Rat Model for Huntington Disease.Frontiers in integrative neuroscience · 2018Article
- Impact of gender and genetics on emotion processing in Parkinson's disease - A multimodal study.NeuroImage. Clinical · 2018Article
- Impaired Emotional Mirroring in Parkinson's Disease-A Study on Brain Activation during Processing of Facial Expressions.Frontiers in neurology · 2017Article
- Abnormal Visual Scanning of Emotionally Evocative Natural Scenes in Huntington's Disease.Frontiers in psychology · 2017Article
- Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington's Disease Mouse Model.Molecular neurobiology · 2016Article
- Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease.Frontiers in behavioral neuroscience · 2016Article
- Patterns of Co-Occurring Gray Matter Concentration Loss across the Huntington Disease Prodrome.Frontiers in neurology · 2016Article
- Is Dysregulation of the HPA-Axis a Core Pathophysiology Mediating Co-Morbid Depression in Neurodegenerative Diseases?Frontiers in psychiatry · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complex phenotype of Huntington's disease (HD) encompasses motor, psychiatric and cognitive dysfunctions, including early impairments in emotion recognition. In this first functional magnetic resonance imaging study, we investigated emotion-processing deficits in 14 manifest HD patients and matched controls. An emotion recognition task comprised short video clips displaying one of six basic facial expressions (sadness, happiness, disgust, fear, anger and neutral). Structural changes between patients and controls were assessed by means of voxel-based morphometry. Along with deficient recognition of negative emotions, patients exhibited predominantly lower neural response to stimuli of negative valences in the amygdala, hippocampus, striatum, insula, cingulate and prefrontal cortices, as well as in sensorimotor, temporal and visual areas. Most of the observed reduced activity patterns could not be explained merely by regional volume loss. Reduced activity in the thalamus during fear correlated with lower thalamic volumes. During the processing of sadness, patients exhibited enhanced amygdala and hippocampal activity along with reduced recruitment of the medial prefrontal cortex. Higher amygdala activity was related to more pronounced amygdala atrophy and disease burden. Overall, the observed emotion-related dysfunctions in the context of structural neurodegeneration suggest both disruptions of striatal-thalamo-cortical loops and potential compensation mechanism with greater disease severity in manifest HD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.