Evidence map›Paper›PMID 23482412›Full record

ReviewWorld journal of gastroenterology2013

DNA and histone methylation in gastric carcinogenesis.

Danielle Queiroz Calcagno, Carolina Oliveira Gigek, Elizabeth Suchi Chen, Rommel Rodriguez Burbano, Marília de Arruda Cardoso Smith

Abstract readReview
In one paragraph

Review in World journal of gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Review
  2. Article
  3. Carcinogenesis trajectories.Frontiers in cell and developmental biology · 2025
    Article
  4. Article
  5. Review
  6. Review
  7. Gut and liver · 2023
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. TERRA Gene Expression in Gastric Cancer: Role of hTERT.Journal of gastrointestinal cancer · 2021
    Review
  17. Review
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Danielle Queiroz CalcagnoDepartment of Morphology and Genetics, Federal University of Sao Paulo, Sao Paulo, SP 04023-900, Brazil. danicalcagno@gmail.com
Carolina Oliveira Gigek
Elizabeth Suchi Chen
Rommel Rodriguez Burbano
Marília de Arruda Cardoso Smith

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic alterations contribute significantly to the development and progression of gastric cancer, one of the leading causes of cancer death worldwide. Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA, and these changes lead to transcriptional activation or silencing of the gene. Over the years, the study of epigenetic processes has increased, and novel therapeutic approaches that target DNA methylation and histone modifications have emerged. A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment. Here, we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome.

Indexed as

DNA MethylationEpigenesis, GeneticAnimalsAntineoplastic AgentsCell Transformation, NeoplasticGene Expression Regulation, NeoplasticHistonesHumansMolecular Targeted TherapyStomach NeoplasmsAntineoplastic AgentsHistonesDNA methylationEpigeneticGastric cancerGastric carcinogenesisHistone methylation

Identifiers

PMID23482412
PMCPMC3587474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.