ReviewBioorganic & medicinal chemistry letters2013
The mammalian clock and chronopharmacology.
Review in Bioorganic & medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Phosphorylation and Circadian Molecular Timing.Frontiers in physiology · 2020Pooled it
- REV-ERBs as regulators of circadian rhythm, neuroinflammation, and glial lipid homeostasis in Alzheimer's disease. A narrative review.British journal of biomedical science · 2026Review
- Disruption of circadian rhythm as a potential pathogenesis of nocturia.Nature reviews. Urology · 2025Review
- Nuclear receptor protein: REV-ERB.Northern clinics of Istanbul · 2025Review
- Prevalence and risk factors of sub-health and circadian rhythm disorder of cortisol, melatonin, and temperature among Chinese midwives.Frontiers in public health · 2023Article
- The role of REV-ERB in NASH.Acta pharmacologica Sinica · 2022Article
- Chronopharmacology in Therapeutic Drug Monitoring-Dependencies between the Rhythmics of Pharmacokinetic Processes and Drug Concentration in Blood.Pharmaceutics · 2021Review
- Circadian rhythm as a therapeutic target.Nature reviews. Drug discovery · 2021Review
- Circadian Clock Regulates Inflammation and the Development of Neurodegeneration.Frontiers in cellular and infection microbiology · 2021Review
- Genetics of Circadian Rhythms.Neurologic clinics · 2019Review
- Entrainment of superoxide rhythm by menadione in HCT116 colon cancer cells.Scientific reports · 2019Article
- The endogenous circadian clock programs animals to eat at certain times of the 24-hour day: What if we ignore the clock?Physiology & behavior · 2018Review
- The circadian clock modulates anti-cancer properties of curcumin.BMC cancer · 2016Article
- Dosing-time contributes to chronotoxicity of clofarabine in mice via means other than pharmacokinetics.The Kaohsiung journal of medical sciences · 2016Article
- Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Analysis of polymorphisms in the circadian-related genes and breast cancer risk in Norwegian nurses working night shifts.Breast cancer research : BCR · 2013Article
- Chronopharmacology of glucocorticoids.Advanced drug delivery reviewsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Increases in our understanding of the molecular control of circadian rhythms and subsequent signaling pathways has allowed for new therapeutic drug targets to be identified as well as for a better understanding of how to more efficaciously and safely utilize current drugs. Here, we review recent advances in targeting components of the molecular clock in mammals for the development of novel therapeutics as well as describe the impact of the circadian rhythm on drug efficacy and toxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.