ArticleMobile genetic elements2012
Mobility of DNA sequence recognition domains in DNA methyltransferases suggests epigenetics-driven adaptive evolution.
Article in Mobile genetic elements, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Methylation Dynamics inMicroorganisms · 2026Article
- Host-encoded DNA methyltransferases modify the epigenome and host tropism of invading phages.iScience · 2025Article
- Epigenetic modulation of fungal pathogens: a focus onFrontiers in microbiology · 2024Review
- Multigenerational Effects of Graphene Oxide Nanoparticles onInternational journal of molecular sciences · 2023Article
- Base-excision restriction enzymes: expanding the world of epigenetic immune systems.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023Article
- Differences in the Accessory Genomes and Methylomes of Strains of Streptococcus equi subsp.Microbiology spectrum · 2022Article
- Genomic Features and Pervasive Negative Selection inMicrobiology spectrum · 2022Article
- Diverse DNA modification in marine prokaryotic and viral communities.Nucleic acids research · 2022Article
- Article
- Networking and Specificity-Changing DNA Methyltransferases inFrontiers in microbiology · 2020Article
- Article
- Deciphering bacterial epigenomes using modern sequencing technologies.Nature reviews. Genetics · 2019Review
- Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori.Scientific reports · 2017Article
- Epigenetic regulation of development and pathogenesis in fungal plant pathogens.Molecular plant pathology · 2017Review
- Regulation of genetic flux between bacteria by restriction-modification systems.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Natural C-independent expression of restriction endonuclease in a C protein-associated restriction-modification system.Nucleic acids research · 2016Article
- Lifespan of restriction-modification systems critically affects avoidance of their recognition sites in host genomes.BMC genomics · 2015Article
- Single molecule-level detection and long read-based phasing of epigenetic variations in bacterial methylomes.Nature communications · 2015Article
- The complete methylome of Helicobacter pylori UM032.BMC genomics · 2015Article
- Restriction-modification system with methyl-inhibited base excision and abasic-site cleavage activities.Nucleic acids research · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is one of the best studied epigenetic modifications observed in prokaryotes as well as eukaryotes. It affects nearby gene expression. Most DNA methylation reactions in prokaryotes are catalyzed by a DNA methyltransferase, the modification enzyme of a restriction-modification (RM) system. Its target recognition domain (TRD) recognizes a specific DNA sequence for methylation. In this commentary, we review recent evidence for movement of TRDs between non-orthologous genes and movement within a gene. These movements are likely mediated by DNA recombination machinery, and are expected to alter the methylation status of a genome. Such alterations potentially lead to changes in global gene expression pattern and various phenotypes. The targets of natural selection in adaptive evolution might be these diverse methylomes rather than diverse genome sequences, the target according to the current paradigm in biology. This "epigenetics-driven adaptive evolution" hypothesis can explain several observations in the evolution of prokaryotes and eukaryotes.
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