ArticleNature communications2013
The transcriptional repressor NKAP is required for the development of iNKT cells.
Article in Nature communications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 52 citations in OpenAlex.
- Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment.Cell discovery · 2023Article
- Review
- Natural Killer T Lymphocytes Integrate Innate Sensory Information and Relay Context to Effector Immune Responses.Critical reviews in immunology · 2021Review
- Genetic Analysis of iNKT Cell Development and Function.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Nuclear Factor-κB Activating Protein Plays an Oncogenic Role in Neuroblastoma Tumorigenesis and Recurrence Through the Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway.Frontiers in cell and developmental biology · 2020Article
- NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway.Experimental and therapeutic medicine · 2019Article
- The Transcription Factor PLZF Is Necessary for the Development and Function of Mouse Basophils.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The Interaction between NKAP and HDAC3 Is Critical for T Cell Maturation.ImmunoHorizons · 2019Article
- NKAP alters tumor immune microenvironment and promotes glioma growth via Notch1 signaling.Journal of experimental & clinical cancer research : CR · 2019Article
- The Role of the Thymus in the Immune Response.Thoracic surgery clinics · 2019Review
- NKAP Must Associate with HDAC3 to Regulate Hematopoietic Stem Cell Maintenance and Survival.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- NKAP Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors.Frontiers in cell and developmental biology · 2019Article
- Histone deacetylase function in CD4Nature reviews. Immunology · 2018Review
- Article
- The Role of Autophagy in iNKT Cell Development.Frontiers in immunology · 2018Review
- How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets.Frontiers in immunology · 2018Review
- The corepressor NCOR1 regulates the survival of single-positive thymocytes.Scientific reports · 2017Article
- Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.The Journal of biological chemistry · 2017Article
- Deacetylase activity of histone deacetylase 3 is required for productiveProceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T cell development is blocked at the double-positive stage. This cell-intrinsic block is not due to decreased survival or failure to rearrange the invariant Vα14-Jα18 T cell receptor-α chain, but is rescued by overexpression of a rec-Vα14-Jα18 transgene at the double-positive stage, thus defining a role for NKAP in selection into the invariant natural killer T cell lineage. Importantly, deletion of the NKAP-associated protein histone deacetylase 3 causes a similar block in the invariant natural killer T cell development, indicating that NKAP and histone deacetylase 3 functionally interact to control invariant natural killer T cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.