ArticleSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Study of the cytoxin-associated gene a (CagA gene) in Helicobacter pylori using gastric biopsies of Iraqi patients.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks: A meta-analysis.Medicine · 2017Pooled it
- Antimicrobial resistance and virulence patterns ofInfectious medicine · 2026Article
- Insights into the oral microbiota in human systemic cancers.Frontiers in microbiology · 2024Review
- The high sensitivity and specificity of rapid urease test in diagnosis ofIranian journal of microbiology · 2022Article
- EPIYA Motif Genetic Characterization fromAdvanced biomedical research · 2022Article
- Diagnosis ofJournal of clinical medicine · 2021Article
- EPIYA motifs ofNew microbes and new infections · 2021Article
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- Determination ofHeliyon · 2020Article
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- Microbes in Tumoral In Situ Tissues and in Tumorigenesis.Frontiers in cellular and infection microbiology · 2020Review
- Role of the microbiome in occurrence, development and treatment of pancreatic cancer.Molecular cancer · 2019Review
- The microbiota and microbiome in pancreatic cancer: more influential than expected.Molecular cancer · 2019Review
- Association Between Gastric Lymphoid Follicles (Precursor Of MALT Lymphomas) AndClinical and experimental gastroenterology · 2019Article
- Survival of Helicobacter pylori in gastric acidic territory.Helicobacter · 2017Review
- Prevalence of SpecificJournal of clinical and diagnostic research : JCDR · 2017Article
- Microbiome and pancreatic cancer: A comprehensive topic review of literature.World journal of gastroenterology · 2017Review
- Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma.World journal of gastrointestinal pathophysiology · 2016Review
- Different distribution of Helicobacter pylori EPIYA- cagA motifs and dupA genes in the upper gastrointestinal diseases and correlation with clinical outcomes in iranian patients.Gastroenterology and hepatology from bed to bench · 2015Article
- Article
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5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe Helicobacter pylori CagA gene is a major virulence factor that plays an important role in gastric pathologies. The size variation of CagA gene, which is dependent on the 3' repeat region, contains one or more Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs and CagA multimerization (CM) motifs. Four segments flanking the EPIYA motifs, EPIYA -A, -B, -C, or -D, were reported to play a crucial role in the pathogenesis of H. pylori infection. The aim was to determine the roles of EPIYA segments and CM motifs in gastroduodenal pathogenesis in an Iraqi population. PATIENTS AND
methodsGastric biopsies were collected from 210 patients with gastritis, duodenal ulcer (DU), gastric ulcer (GU), and gastric cancer (GC). The EPIYA motif genotyping was determined by polymerase chain reaction and sequencing. The differences in age, gender, and CagA EPIYA motifs of H. pylori between GC, DU, GU and gastritis patients were analyzed using a χ(2) -test.
resultsA total of 22 (45.8%) strains had three copies of EPIYA (ABC type), 2 (4.16%) had four copies (ABCC type), 6 (12.7%) had five copies (ABCCC type), 13 (27.08%) had two copies (AB type), 3 (6.25%) had the BC, and 2 (4.17%) had AC motif. The alignment of the deduced protein sequences confirmed that there were no East Asian type EPIYA-D sequences in Iraqi strains. A significant association was found between increase in number of EPIYA-C motifs and GU (P ≤ 0.01) compared with gastritis.
conclusionsThe structure of the 3' region of the CagA gene in Iraqi strains was Western type with a variable number of EPIYA-C and CM motifs. A significant association was found between increase in number of EPIYA-C motifs and GU compared with gastritis indicating predictive association with the severity of the disease. The GenBank accession numbers for the partial CagA nucleotide sequences determined in this study are JX164093-JX164112.
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