Evidence map›Paper›PMID 23481067›Full record

ArticleThe Indian journal of medical research2013

Genotyping of erythromycin resistant group C & G streptococci isolated in Chennai, south India.

D Prabu, Thangam Menon

Abstract read
In one paragraph

Article in The Indian journal of medical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

D PrabuDepartment of Microbiology, Dr A.L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, India.
Thangam Menon

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND &

objectivesIncreasing resistance to erythromycin has been observed worldwide in group C and group G streptococci (GCS/GGS). The information available from India is scanty. The aim of the study was to identify erythromycin resistant GCS/GGS isolates in Chennai, south India, and to compare erythromycin resistant genotypes with emm types.

methodsOne hundred and thirty one GCS/GGS isolates were tested for erythromycin resistance by disc diffusion and agar dilution methods. Erythromycin resistance genotypes [erm(A), erm(B) and mef(A)] were determined by a multiplex PCR. emm types of erythromycin resistant GCS/GGS isolates was also assessed using emm gene sequencing method.

resultsSixteen of the 131 isolates (12.21%) were resistant to erythromycin. Majority of the isolates were GGS (15/16). Eight of the 16 (50%) were S. dysgalactiae subsps. equisimilis. Twelve isolates (75%) were MLS B phenotype and four (25%) were M phenotype. Of the 12 isolates which exhibited MLS B resistance, seven showed cMLS B phenotype and were positive for erm(B) gene. The remaining five were iMLS B phenotype of which three were positive for erm(A) gene and two for erm(B) gene. erm(A) was common among carriers whereas erm(B) was common among clinical isolates. INTERPRETATION &

conclusionsMLS B was the predominant phenotype and erm(B) was the common genotype in the present study. The emm type stC1400.0 was frequently associated with erythromycin resistant GCS/GGS in our study.

Indexed as

GenotypeAnti-Bacterial AgentsDrug Resistance, BacterialErythromycinHumansIndiaMicrobial Sensitivity TestsStreptococcal InfectionsStreptococcusStreptococcus pneumoniaeAnti-Bacterial AgentsErythromycin

Identifiers

PMID23481067
PMCPMC3657882

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