ArticleInternational endodontic journal2013
Evaluation of a nonthermal plasma needle to eliminate ex vivo biofilms in root canals of extracted human teeth.
Article in International endodontic journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Disinfection of dental root canals by cold atmospheric plasma: a systematic review and meta-analysis of dental biofilm.Frontiers in oral health · 2024Pooled it
- Exploring the Efficacy of Low-Temperature Plasmas on Oral Biofilms: A Scoping Review.Medical sciences (Basel, Switzerland) · 2025Article
- Development and characterization of a spark plasma device designed for medical and aesthetic applications.Heliyon · 2024Article
- Non-Thermal Atmospheric Pressure Plasma Application in Endodontics.Biomedicines · 2023Review
- AnBiomaterial investigations in dentistry · 2023Article
- Antibacterial Efficacy of Cold Atmospheric Plasma, Photodynamic Therapy with Two Photosensitizers, and Diode Laser on Primary Mandibular Second Molar Root Canals Infected withInternational journal of dentistry · 2023Article
- Aurora Borealis in dentistry: The applications of cold plasma in biomedicine.Materials today. Bio · 2022Review
- The Antimicrobial Effect of Cold Atmospheric Plasma against Dental Pathogens-A Systematic Review of In-Vitro Studies.Antibiotics (Basel, Switzerland) · 2021Review
- The Emerging Role of Cold Atmospheric Plasma in Implantology: A Review of the Literature.Nanomaterials (Basel, Switzerland) · 2020Review
- Medically important biofilms and non-thermal plasma.World journal of microbiology & biotechnology · 2018Review
- A Proposal of Remedies for Oral Diseases Caused by Candida: A Mini Review.Frontiers in microbiology · 2018Review
- Generation and Role of Reactive Oxygen and Nitrogen Species Induced by Plasma, Lasers, Chemical Agents, and Other Systems in Dentistry.Oxidative medicine and cellular longevity · 2017Review
- Cold air plasma to decontaminate inanimate surfaces of the hospital environment.Applied and environmental microbiology · 2014Article
- Cold Atmospheric Plasma: methods of production and application in dentistry and oncology.Medical gas research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
aimTo evaluate the efficacy of a nonthermal plasma (NTP) at atmospheric pressure on ex vivo biofilm in root canals of extracted teeth. METHODOLOGY: Intracanal contents from three teeth with root canal infections were collected, pooled and grown in thirty-five microCT-mapped root canals of extracted and instrumented human teeth. One group of teeth was treated with NTP, another with 6% NaOCl and one set was left untreated. The intracanal contents from twenty-seven teeth (nine teeth in each group) were plated on agar and colony forming units were determined. Parametric test of one-way analysis of variance (anova) was used to analyse statistical significance. The remaining teeth were cut open, stained with LIVE/DEAD(®) and examined with confocal laser scanning microscopy.
resultsThe untreated root canals were covered with biofilm of varying thickness. Treatment with nonthermal plasma decreased the number of viable bacteria in biofilms by one order of magnitude, whilst the NaOCl control achieved a reduction of more than four magnitudes. Both the NTP and the NaOCl treatment results were significantly different from the negative control (P < 0.05).
conclusionThe nonthermal plasma displayed antimicrobial activity against endodontic biofilms in root canals, but was not as effective as the use of 6% NaOCl.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.