ArticleClinical and experimental immunology2013
Human intrahepatic biliary epithelial cells engulf blebs from their apoptotic peers.
Article in Clinical and experimental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- A high bile acid environment promotes apoptosis and inhibits migration in pancreatic cancer.Bioengineered · 2022Article
- Decreased CD57 expression of natural killer cells enhanced cytotoxicity in patients with primary sclerosing cholangitis.Frontiers in immunology · 2022Article
- MC-LR-induced interaction between M2 macrophage and biliary epithelial cell promotes biliary epithelial cell proliferation and migration through regulating STAT3.Cell biology and toxicology · 2021Article
- Cell-in-Cell Structures in the Liver: A Tale of Four E's.Frontiers in immunology · 2020Review
- Abnormal Expression of ERα in Cholangiocytes of Patients With Primary Biliary Cholangitis Mediated Intrahepatic Bile Duct Inflammation.Frontiers in immunology · 2019Article
- Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis.Frontiers in immunology · 2018Review
- Exploring pathogenesis of primary biliary cholangitis by proteomics: A pilot study.World journal of gastroenterology · 2017Observational
- Toward solving the etiological mystery of primary biliary cholangitis.Hepatology communications · 2017Article
- The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis.Cellular & molecular immunology · 2017Article
- Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1.Journal of hepatology · 2016Article
- Animal models of primary biliary cirrhosis.Clinical reviews in allergy & immunology · 2015Review
- Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis.Journal of autoimmunity · 2015Article
- Primary biliary cirrhosis is a generalized autoimmune epithelitis.International journal of molecular sciences · 2015Review
- Targeting apoptosis in autoimmune hepatitis.Digestive diseases and sciences · 2014Review
- Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells.Clinical and experimental immunology · 2014Article
- Innate immunity drives xenobiotic-induced murine autoimmune cholangitis.Clinical and experimental immunology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
The phagocytic clearance of apoptotic cells is critical for tissue homeostasis; a number of non-professional phagocytic cells, including epithelial cells, can both take up and process apoptotic bodies, including the release of anti-inflammatory mediators. These observations are particularly important in the case of human intrahepatic biliary cells (HiBEC), because such cells are themselves a target of destruction in primary biliary cirrhosis, the human autoimmune disease. To address the apoptotic ability of HiBECs, we have focused on their ability to phagocytize apoptotic blebs from autologous HiBECs. In this study we report that HiBEC cells demonstrate phagocytic function from autologous HiBEC peers accompanied by up-regulation of the chemokines CCL2 [monocyte chemotactic protein-1 (MCP-1)] and CXCL8 [interleukin (IL)-8]. In particular, HiBEC cells express the phagocytosis-related receptor phosphatidylserine receptors (PSR), implying that HiBECs function through the 'eat-me' signal phosphatidylserine expressed by apoptotic cells. Indeed, although HiBEC cells acquire antigen-presenting cell (APC) function, they do not change the expression of classic APC function surface markers after engulfment of blebs, both with and without the presence of Toll-like receptor (TLR) stimulation. These results are important not only for understanding of the normal physiological function of HiBECs, but also explain the inflammatory potential and reduced clearance of HiBEC cells following the inflammatory cascade in primary biliary cirrhosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.