Evidence map›Paper›PMID 23480179›Full record

ReviewClinical and experimental immunology2013

Protecting against plague: towards a next-generation vaccine.

E D Williamson, P C F Oyston

Open access · greenAbstract readReview
In one paragraph

Review in Clinical and experimental immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 54 citations in OpenAlex.

  1. Trial
  2. An adenoviral-vectored vaccine protects mice against aerosol challenge with Yersinia pestis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Optimised Heterologous Expression and Functional Analysis of theInternational journal of molecular sciences · 2021
    Article
  9. Plague vaccines: new developments in an ongoing search.Applied microbiology and biotechnology · 2021
    Review
  10. Article
  11. Article
  12. Article
  13. Polymorphism in theFrontiers in immunology · 2019
    Article
  14. Review
  15. Article
  16. Targeting of theNPJ vaccines · 2018
    Article
  17. Particulate delivery systems for vaccination against bioterrorism agents and emerging infectious pathogens.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

E D WilliamsonBiomedical Sciences Department, Defence Science and Technology Laboratory, Salisbury, Wilts, UK. dewilliamson@dstl.gov.uk
P C F Oyston
Defence Science and Technology Laboratory · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The causative organism of plague is the bacterium Yersinia pestis. Advances in understanding the complex pathogenesis of plague infection have led to the identification of the F1- and V-antigens as key components of a next-generation vaccine for plague, which have the potential to be effective against all forms of the disease. Here we review the roles of F1- and V-antigens in the context of the range of virulence mechanisms deployed by Y. pestis, in order to develop a greater understanding of the protective immune responses required to protect against plague.

Indexed as

VaccinationAntibodies, BacterialAntigens, BacterialBacterial ProteinsGene ExpressionHumansImmune EvasionImmunity, CellularImmunity, HumoralPlaguePlague VaccinePore Forming Cytotoxic ProteinsVirulenceYersinia pestisAntibodies, BacterialAntigens, BacterialBacterial Proteinscaf1 protein, Yersinia pestisLcrV protein, YersiniaPlague VaccinePore Forming Cytotoxic Proteins

Identifiers

PMID23480179
PMCPMC3719925
OpenAlexW1563212223

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.