ArticleThe Journal of cell biology2013
Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Notch signaling mediates olfactory multiciliated cell specification.Cells & development · 2021Article
- Ciliary GPCR-based transcriptome as a key regulator of cilia length control.FASEB bioAdvances · 2021Article
- Cilia in the developing zebrafish ear.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development.Current biology : CB · 2019Article
- RER1 enhances carcinogenesis and stemness of pancreatic cancer under hypoxic environment.Journal of experimental & clinical cancer research : CR · 2019Article
- Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch signaling pathway.EMBO reports · 2018Article
- Rer1-mediated quality control system is required for neural stem cell maintenance during cerebral cortex development.PLoS genetics · 2018Article
- Assaying sensory ciliopathies using calcium biosensor expression in zebrafish ciliated olfactory neurons.Cilia · 2018Article
- Article
- The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.Scientific reports · 2017Article
- The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.PloS one · 2017Article
- Dynamin Binding Protein (Tuba) Deficiency Inhibits Ciliogenesis and Nephrogenesis in Vitro and in Vivo.The Journal of biological chemistry · 2016Article
- Rer1p regulates the ER retention of immature rhodopsin and modulates its intracellular trafficking.Scientific reports · 2014Article
- Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Zebrafish--on the move towards ophthalmological research.Eye (London, England) · 2014Review
- Primary cilia and kidney injury: current research status and future perspectives.American journal of physiology. Renal physiology · 2013Review
- Activation loop phosphorylation of a protein kinase is a molecular marker of organelle size that dynamically reports flagellar length.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Protein quality control by Rer1p in the early secretory pathway: from mechanism to implication in Alzheimer's disease.Alzheimer's research & therapy · 2013Review
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Authors and funding
18 authors at 4 institutions in 2 countries.
Funding
Abstract
Cilia project from the surface of most vertebrate cells and are important for several physiological and developmental processes. Ciliary defects are linked to a variety of human diseases, named ciliopathies, underscoring the importance of understanding signaling pathways involved in cilia formation and maintenance. In this paper, we identified Rer1p as the first endoplasmic reticulum/cis-Golgi-localized membrane protein involved in ciliogenesis. Rer1p, a protein quality control receptor, was highly expressed in zebrafish ciliated organs and regulated ciliary structure and function. Both in zebrafish and mammalian cells, loss of Rer1p resulted in the shortening of cilium and impairment of its motile or sensory function, which was reflected by hearing, vision, and left-right asymmetry defects as well as decreased Hedgehog signaling. We further demonstrate that Rer1p depletion reduced ciliary length and function by increasing γ-secretase complex assembly and activity and, consequently, enhancing Notch signaling as well as reducing Foxj1a expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.