ArticleProceedings of the National Academy of Sciences of the United States of America2013
Intracellular transport of insulin granules is a subordinated random walk.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed, 369 citations in OpenAlex.
- Article
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- Enhancing fluorescence correlation spectroscopy with machine learning to infer anomalous molecular motion.Biophysical journal · 2025Article
- Modeling telomere shortening process.Quantitative biology (Beijing, China) · 2025Article
- Heterogeneous model for superdiffusive movement of dense core vesicles in C. elegans.Scientific reports · 2025Article
- Impact of the Microtubule Cytoskeleton on Insulin Transport in Beta Cells: A 3D Computational Study.bioRxiv : the preprint server for biology · 2025Article
- What determines sub-diffusive behavior in crowded protein solutions?Biophysical journal · 2024Article
- Unveiling nanoscale optical signatures of cytokine-induced β-cell dysfunction.Scientific reports · 2023Article
- Ensemble heterogeneity mimics ageing for endosomal dynamics within eukaryotic cells.Scientific reports · 2023Article
- Electro-optical Study of the Anomalous Rotational Diffusion in Polymer Solutions.Macromolecules · 2023Article
- Single-molecule analysis of intracellular insulin granule behavior and its application to analyzing cytoskeletal dependence and pathophysiological implications.Frontiers in physiology · 2023Article
- Insulin secretion hot spots in pancreatic β cells as secreting adhesions.Frontiers in cell and developmental biology · 2023Article
- The Fokker-Planck equation of the superstatistical fractional Brownian motion with application to passive tracers inside cytoplasm.Royal Society open science · 2022Article
- In Silico Studies of Active Probe Dynamics in Crowded Media.ACS omega · 2022Review
- Non-ergodicity of a globular protein extending beyond its functional timescale.Chemical science · 2022Article
- Organization and dynamics of the cortical complexes controlling insulin secretion in β-cells.Journal of cell science · 2022Article
- Microtubules in Pancreatic β Cells: Convoluted Roadways Toward Precision.Frontiers in cell and developmental biology · 2022Review
- Lévy Walk Dynamics in an External Constant Force Field in Non-Static Media.Journal of statistical physics · 2022Article
- β-Cell Pathophysiology: A Review of Advanced Optical Microscopy Applications.International journal of molecular sciences · 2021Review
21 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We quantitatively analyzed particle tracking data on insulin granules expressing fluorescent fusion proteins in MIN6 cells to better understand the motions contributing to intracellular transport and, more generally, the means for characterizing systems far from equilibrium. Care was taken to ensure that the statistics reflected intrinsic features of the individual granules rather than details of the measurement and overall cell state. We find anomalous diffusion. Interpreting such data conventionally requires assuming that a process is either ergodic with particles working against fluctuating obstacles (fractional brownian motion) or nonergodic with a broad distribution of dwell times for traps (continuous-time random walk). However, we find that statistical tests based on these two models give conflicting results. We resolve this issue by introducing a subordinated scheme in which particles in cages with random dwell times undergo correlated motions owing to interactions with a fluctuating environment. We relate this picture to the underlying microtubule structure by imaging in the presence of vinblastine. Our results provide a simple physical picture for how diverse pools of insulin granules and, in turn, biphasic secretion could arise.
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