Trial reportThe Journal of infectious diseases2013
Systemic immune activation and microbial translocation in dual HIV/tuberculosis-infected subjects.
Trial report in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Microbial product translocation and mortality in adults hospitalised with HIV-associated tuberculosis: a prospective observational cohort study.Research square · 2026Article
- Bacillus Calmette-Guérin (BCG) Vaccination and the Immune-Brain Axis: Implications for Neuroprotection and Neurodegenerative Disease.Vaccines · 2026Review
- Global burden of tuberculosis attributable to diet low in whole grains from 1990 to 2021, with projection to 2045.Frontiers in nutrition · 2025Article
- Active Tuberculosis Is Associated with Depletion of HIV-Specific CD4 and CD8 T Cells in People with HIV.AIDS research and human retroviruses · 2024Article
- Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease.Circulation research · 2024Review
- Heightened Microbial Translocation Is a Prognostic Biomarker of Recurrent Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Evaluation of Host Serum Protein Biomarkers of Tuberculosis in sub-Saharan Africa.Frontiers in immunology · 2021Article
- Mycobacterium tuberculosis co-infection is associated with increased surrogate marker of the HIV reservoir.AIDS research and therapy · 2020Article
- Chronic Immune Activation in TB/HIV Co-infection.Trends in microbiology · 2020Review
- Elevated Plasma Levels of sCD14 and MCP-1 Are Associated With HIV Associated Neurocognitive Disorders Among Antiretroviral-Naive Individuals in Nigeria.Journal of acquired immune deficiency syndromes (1999) · 2020Article
- Elevated circulating levels of monocyte activation markers among tuberculosis patients with diabetes co-morbidity.Immunology · 2019Article
- Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection.Nature reviews. Microbiology · 2018Review
- Plasma Cytokine Predictors of Tuberculosis Recurrence in Antiretroviral-Treated Human Immunodeficiency Virus-infected Individuals from Durban, South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Article
- Immune Activation at Sites of HIV/TB Co-Infection Contributes to the Pathogenesis of HIV-1 Disease.PloS one · 2016Article
- Raised Venous Lactate and Markers of Intestinal Translocation Are Associated With Mortality Among In-Patients With HIV-Associated TB in Rural South Africa.Journal of acquired immune deficiency syndromes (1999) · 2015Observational
- Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV.EBioMedicine · 2015Article
- Observational
- Short communication: circulating plasma HIV-1 viral protein R in dual HIV-1/tuberculosis infection.AIDS research and human retroviruses · 2014Article
- Article
- Pattern of microbial translocation in patients living with HIV-1 from Vietnam, Ethiopia and Sweden.Journal of the International AIDS Society · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSystemic immune activation is a strong predictor of progression of human immunodeficiency virus type 1 (HIV-1) disease and a prominent feature of infection with Mycobacterium tuberculosis.
objectiveTo understand the role of systemic immune activation and microbial translocation in HIV/tuberculosis dually infected patients over the full spectrum of HIV-1 immunodeficiency, we studied circulating sCD14 and lipopolysaccharide (LPS) and their relationship to HIV-1 activity.
methodsTwo cohorts of HIV/tuberculosis subjects defined by CD4 T-cell count at time of diagnosis of tuberculosis were studied: those with low (<350/μL) and those with high (≥ 350/μL) CD4 T-cell count. Circulating soluble CD14 (sCD14) and LPS were assessed.
resultsLevels of sCD14 were higher in HIV/tuberculosis with high (≥ 350/μL) as compared to low CD4 T-cell count (P < .001). Whereas sCD14 levels remained elevated in HIV/tuberculosis subjects with lower CD4 T-cell counts despite treatment of tuberculosis, in HIV/tuberculosis patients with higher CD4 T-cell count (≥ 350/μL), levels declined regardless of whether highly active antiretroviral therapy (HAART) was included with the anti-tuberculosis regimen. Circulating LPS levels in HIV/tuberculosis patients with CD4 T-cell count ≥ 350/μL were unaffected by treatment of tuberculosis with or without HAART.
conclusionDuring HIV/tuberculosis, systemic immune activation is dissociated from microbial translocation. Changes in circulating sCD14 and LPS are dependent on CD4 T-cell count.
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