ArticleClinical orthopaedics and related research2013
Cumulative effects of bone and soft tissue injury on systemic inflammation: a pilot study.
Article in Clinical orthopaedics and related research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Association between the duration of skeletal traction and postoperative pneumonia in elderly hip fractures.BMC geriatrics · 2026Article
- Regional anesthesia is associated with improved metastasis free survival after surgical resection of bone sarcomas.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- The Impact of Body Mass Composition on Outcome in Multiple Traumatized Patients-Results from the Fourth Thoracic and Third Lumbar Vertebrae: A Single-Center Retrospective Observational Study.Journal of clinical medicine · 2023Article
- Assessment of alternative techniques to quantify the effect of injury on soft tissue in closed ankle and pilon fractures.PloS one · 2022Article
- Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
- Epidemiology of open tibia fractures in a population-based database: update on current risk factors and clinical implications.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019Article
- Correction to: A new multiple trauma model of the mouse.BMC musculoskeletal disorders · 2019Article
- Trauma Severity and Its Impact on Local Inflammation in Extremity Injury-Insights From a Combined Trauma Model in Pigs.Frontiers in immunology · 2019Article
- Age Dependence of Systemic Bone Loss and Recovery Following Femur Fracture in Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Systemic Bone Loss After Fracture.Clinical reviews in bone and mineral metabolism · 2018Article
- A new multiple trauma model of the mouse.BMC musculoskeletal disorders · 2017Article
- Trabecular bone loss at a distant skeletal site following noninvasive knee injury in mice.Journal of biomechanical engineering · 2015Article
- Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications.Mediators of inflammation · 2015Review
- Local inflammation in fracture hematoma: results from a combined trauma model in pigs.Mediators of inflammation · 2015Article
- Symposium: Tscherne Festschrift: editorial comment.Clinical orthopaedics and related research · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn multiply injured patients, bilateral femur fractures invoke a substantial systemic inflammatory impact and remote organ dysfunction. However, it is unclear whether isolated bone or soft tissue injury contributes to the systemic inflammatory response and organ injury after fracture. QUESTIONS/PURPOSES: We therefore asked whether the systemic inflammatory response and remote organ dysfunction are attributable to the bone fragment injection, adjacent soft tissue injury, or both.
methodsMale C57/BL6 mice (8-10 weeks old, 20-30 g) were assigned to four groups: bone fragment injection (BF, n = 9) group; soft tissue injury (STI, n = 9) group; BF + STI (n = 9) group, in which both insults were applied; and control group, in which neither insult was applied. Animals were sacrificed at 6 hours. As surrogates for systemic inflammation, we measured serum IL-6, IL-10, osteopontin, and alanine aminotransferase (ALT) and nuclear factor (NF)-κB and myeloperoxidase (MPO) in the lung.
resultsThe systemic inflammatory response (mean IL-6 level) was similar in the BF (61.8 pg/mL) and STI (67.9 pg/mL) groups. The combination (BF + STI) of both traumatic insults induced an increase in mean levels of inflammatory parameters (IL-6: 189.1 pg/mL) but not in MPO levels (1.21 ng/mL) as compared with the BF (0.82 ng/mL) and STI (1.26 ng/mL) groups. The model produced little evidence of remote organ inflammation.
conclusionsOur findings suggest both bone and soft tissue injury are required to induce systemic changes. The absence of remote organ inflammation suggests further fracture-associated factors, such as hemorrhage and fat liberation, may be more critical for induction of remote organ damage. CLINICAL RELEVANCE: Both bone and soft tissue injuries contribute to the systemic inflammatory response.
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