ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2014
Influence of basal support and early loading on bone cartilage healing in press-fitted osteochondral autografts.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Autologous osteochondral transplantation for osteochondral lesions of the talus: high rate of return to play in the athletic population.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021Pooled it
- Article
- Article
- An Expert Consensus Statement on the Management of Large Chondral and Osteochondral Defects in the Patellofemoral Joint.Orthopaedic journal of sports medicine · 2020Article
- Treatment of osteochondral defects: chondrointegration of metal implants improves after hydroxyapatite coating.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Current Trends in the Evaluation of Osteochondral Lesion Treatments: Histology, Histomorphometry, and Biomechanics in Preclinical Models.BioMed research international · 2019Review
- Autologous osteochondral transplantation for osteochondral lesions of the talus in an athletic population.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2016Article
- Review of the biomechanics and biotribology of osteochondral grafts used for surgical interventions in the knee.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2015Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe influence of basal graft support combined to early loading following an osteochondral autograft procedure is unclear. It was hypothesized that bottomed grafts may allow for early mobilization by preventing graft subsidence and leading to better healing.
methodsOsteochondral autografts were press fitted in the femoral condyles of 24 sheep (one graft per animal). In the unbottomed group (n = 12), a gap of 2 mm was created between graft and recipient bone base. In the bottomed group (n = 12), the graft firmly rested on recipient bone. Animals were allowed immediate postoperative weightbearing. Healing times were 3 and 6 months per group (n = 6 per subgroup). After killing, histological and histomorphometric analyses were performed.
resultsUnbottomed grafts at 3 months showed significantly more graft subsidence (P = 0.024), significantly less mineralized bone (P = 0.028) and significantly worse cartilage and subchondral bone plate healing (P = 0.034) when compared to bottomed grafts. At 6 months, no differences were seen. Compared to the native situation, unbottomed grafts showed significantly more graft subsidence (P = 0.024), whereas bottomed grafts did not. Cystic lesions were seen in both groups. Osteoclasts were closely related to the degree of bone remodelling.
conclusionIn the animal model, in the case of early loading, bottomed osteochondral autografts have less chance of graft subsidence. Evident subsidence negatively influences the histological healing process. In the osteochondral autograft procedure, full graft support should be aimed for. This may allow for early mobilization, diminish graft subsidence and improve long-term integration.
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