ArticleAntimicrobial agents and chemotherapy2013
Differential distribution of plasmid-mediated quinolone resistance genes in clinical enterobacteria with unusual phenotypes of quinolone susceptibility from Argentina.
Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 59 citations in OpenAlex.
- Tracking Antimicrobial Resistance inFoods (Basel, Switzerland) · 2026Article
- Occurrence of Plasmid-Mediated Quinolone Resistance and Carbapenemase-Encoding Genes inPathogens (Basel, Switzerland) · 2024Observational
- High Prevalence of Plasmid-Mediated Quinolone Resistance among ESBL/AmpC-Producing Enterobacterales from Free-Living Birds in Poland.International journal of molecular sciences · 2023Article
- Genetic Factors That Contribute to Antibiotic Resistance through Intrinsic and Acquired Bacterial Genes in Urinary Tract Infections.Microorganisms · 2023Review
- Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis.Microbiology spectrum · 2021Article
- Genomic Characterization of Multidrug-ResistantFrontiers in veterinary science · 2021Article
- Corrigendum: Transduction as a Potential Dissemination Mechanism of a ClonalFrontiers in microbiology · 2020Article
- Diversity and frequency of resistance and virulence genes inInfection and drug resistance · 2019Article
- Transduction as a Potential Dissemination Mechanism of a ClonalFrontiers in microbiology · 2019Article
- Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient.PloS one · 2019Article
- An evaluation of multidrug-resistant Escherichia coli isolates in urinary tract infections from Aguascalientes, Mexico: cross-sectional study.Annals of clinical microbiology and antimicrobials · 2018Article
- Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces.Scientific reports · 2018Article
- Plasmid-Mediated Quinolone Resistance inFrontiers in microbiology · 2018Article
- Simultaneous Carriage ofFrontiers in microbiology · 2018Article
- Zoonotic Potential and Antibiotic Resistance of Escherichia coli in Neonatal Calves in Uruguay.Microbes and environments · 2017Article
- Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.Applied and environmental microbiology · 2017Article
- Plasmid-Mediated Quinolone-Resistance (Osong public health and research perspectives · 2016Article
- Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245 Klebsiella pneumoniae clones circulating in Spain.The Journal of antimicrobial chemotherapy · 2016Article
- Mechanisms of drug resistance: quinolone resistance.Annals of the New York Academy of Sciences · 2015Review
- Characterization of Tn6238 with a new allele of aac(6')-Ib-cr.Antimicrobial agents and chemotherapy · 2015Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied a collection of 105 clinical enterobacteria with unusual phenotypes of quinolone susceptibility to analyze the occurrence of plasmid-mediated quinolone resistance (PMQR) and oqx genes and their implications for quinolone susceptibility. The oqxA and oqxB genes were found in 31/34 (91%) Klebsiella pneumoniae and 1/3 Klebsiella oxytoca isolates. However, the oqxA- and oqxB-harboring isolates lacking other known quinolone resistance determinants showed wide ranges of susceptibility to nalidixic acid and ciprofloxacin. Sixty of the 105 isolates (57%) harbored at least one PMQR gene [qnrB19, qnrB10, qnrB2, qnrB1, qnrS1, or aac(6')-Ib-cr)], belong to 8 enterobacterial species, and were disseminated throughout the country, and most of them were categorized as susceptible by the current clinical quinolone susceptibility breakpoints. We developed a disk diffusion-based method to improve the phenotypic detection of aac(6')-Ib-cr. The most common PMQR genes in our collection [qnrB19, qnrB10, and aac(6')-Ib-cr] were differentially distributed among enterobacterial species, and two different epidemiological settings were evident. First, the species associated with community-acquired infections (Salmonella spp. and Escherichia coli) mainly harbored qnrB19 (a unique PMQR gene) located in small ColE1-type plasmids that might constitute its natural reservoirs. qnrB19 was not associated with an extended-spectrum β-lactamase phenotype. Second, the species associated with hospital-acquired infections (Enterobacter spp., Klebsiella spp., and Serratia marcescens) mainly harbored qnrB10 in ISCR1-containing class 1 integrons that may also have aac(6')-Ib-cr as a cassette within the variable region. These two PMQR genes were strongly associated with an extended-spectrum β-lactamase phenotype. Therefore, this differential distribution of PMQR genes is strongly influenced by their linkage or lack of linkage to integrons.
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