ArticlePediatric research2013
Quantification of white matter injury following neonatal stroke with serial DTI.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05013736 (Perinatal Stroke), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Perinatal Stroke: Longitudinal Assessment of Infant Brain Organization and Recovery Through Neuroexcitability, Neuroimaging and Motor Development
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early predictors of neurodevelopment after perinatal arterial ischemic stroke: a systematic review and meta-analysis.Pediatric research · 2023Pooled it
- Predicting Outcome After Newborn Stroke: A Lesion Network Mapping Study Leveraging Large-Scale Data.Stroke · 2026Article
- Structural and Functional Imaging of Motor Outcomes in Twins With Perinatal Stroke: A Case Report.Annals of the Child Neurology Society · 2026Article
- Intraoperative sodium range affects white matter microstructure in neonatal congenital heart disease.International journal of cardiology. Congenital heart disease · 2026Article
- Review
- White-Matter Connectivity and General Movements in Infants with Perinatal Brain Injury.Brain sciences · 2025Article
- Cerebral ischemia in the developing brain.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Review
- Structural brain connectivity in children after neonatal stroke: A whole-brain fixel-based analysis.NeuroImage. Clinical · 2022Article
- Focal Ischemic Injury to the Early Neonatal Rat Brain Models Cognitive and Motor Deficits with Associated Histopathological Outcomes Relevant to Human Neonatal Brain Injury.International journal of molecular sciences · 2021Article
- Early prediction of unilateral cerebral palsy in infants at risk: MRI versus the hand assessment for infants.Pediatric research · 2020Article
- In vivo high-resolution diffusion tensor imaging of the developing neonatal rat cortex and its relationship to glial and dendritic maturation.Brain structure & function · 2019Article
- Early human brain development: insights into macroscale connectome wiring.Pediatric research · 2018Article
- Corticospinal tract diffusion properties and robotic visually guided reaching in children with hemiparetic cerebral palsy.Human brain mapping · 2018Article
- Sensory tractography and robot-quantified proprioception in hemiparetic children with perinatal stroke.Human brain mapping · 2017Article
- Long term motor function after neonatal stroke: Lesion localization above all.Human brain mapping · 2015Article
- Left-hemispheric microstructural abnormalities in children with high-functioning autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2015Article
- Functional correlates of central white matter maturation in perinatal period in rabbits.Experimental neurology · 2014Article
- Reproducibility of diffusion tensor imaging in normal subjects: an evaluation of different gradient sampling schemes and registration algorithm.Neuroradiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundDiffusion tensor imaging (DTI) can be used to predict outcome following perinatal arterial ischemic stroke (PAIS), although little is known about white matter changes over time.
methodsInfants with PAIS were serially scanned in the neonatal period (n = 15), at 3 mo (n = 16), and at 24 mo (n = 8). Fractional anisotropy (FA) values in five regions of interest (anterior and posterior limb of the internal capsule, corpus callosum, optic radiation, and posterior thalamic radiation) were obtained and compared with FA values of healthy controls and neurodevelopmental outcome.
resultsIn the neonatal period, no differences in FA values were found. At 3 mo, the six infants who ultimately developed motor deficits showed lower FA values in all affected regions. Four infants developed a visual field defect and showed lower FA values in the affected optic radiation at 3 mo (0.22 vs. 0.29; P = 0.03). Finally, a correlation between FA values of the corpus callosum at 3 mo and the Griffiths developmental quotients was found (r = 0.66; P = 0.03). At 24 mo, a similar pattern was observed.
conclusionNeonatal FA measurements may underestimate the extent of injury following PAIS. FA measurements at 3 mo could be considered a more reliable predictor of neurodevelopmental outcome and correlate with DTI findings at 24 mo.
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