Evidence map›Paper›PMID 23478585›Full record

ArticleThe American journal of tropical medicine and hygiene2013

Human host-derived cytokines associated with Plasmodium vivax transmission from acute malaria patients to Anopheles darlingi mosquitoes in the Peruvian Amazon.

Shira R Abeles, Raul Chuquiyauri, Carlos Tong, Joseph M Vinetz

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Epidemiology of Plasmodium vivax Malaria in Peru.The American journal of tropical medicine and hygiene · 2016
    Article
  8. Accelerating to Zero: Strategies to Eliminate Malaria in the Peruvian Amazon.The American journal of tropical medicine and hygiene · 2016
    Article
  9. Article
  10. Article
  11. Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax.The American journal of tropical medicine and hygiene · 2014
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Shira R AbelesUniversity of California San Diego, San Diego, CA, USA.
Raul Chuquiyauri
Carlos Tong
Joseph M Vinetz
University of California, San Diego · USUniversidad Peruana Cayetano Heredia · PE

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Sugar-feeding behavior of the malaria vector Nyssorhynchus darlingi and development of effective attractive toxic sugar baits (ATSB) to increase intervention success in PeruU19AI089681 · NIAID · YALE UNIVERSITY · PI GAZZINELLI, RICARDO TOSTES · 2010 to 2023
$20.1M
University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
Human Reservoirs of Plasmodium vivax Transmission in the Peruvian AmazonR01AI067727 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VINETZ, JOSEPH M. · 2006 to 2010
$3.4M
Translational Research Development for Endemic Infectious Diseases of AmazoniaD43TW007120 · FIC · YALE UNIVERSITY · PI VINETZ, JOSEPH M. · 2004 to 2020
$3.0M
Patient-Oriented Research in Tropical Infectious DiseasesK24AI068903 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VINETZ, JOSEPH M. · 2006 to 2015
$1.5M
FIC NIH HHS D43 TW007120FIC NIH HHS D43TW007120FIC NIH HHS D43 TW009343FIC NIH HHS R24 TW007988NIAID NIH HHS 1U19AI08968NIAID NIH HHS K24 AI068903NIAID NIH HHS K24AI068903NIAID NIH HHS R01 AI067727NIAID NIH HHS R01AI067727NIAID NIH HHS U19 AI089681
6 · The paper itself

Abstract

Infection of mosquitoes by humans is not always successful in the setting of patent gametocytemia. This study tested the hypothesis that pro- or anti-inflammatory cytokines are associated with transmission of Plasmodium vivax to Anopheles darlingi mosquitoes in experimental infection. Blood from adults with acute, non-severe P. vivax malaria was fed to laboratory-reared F1 An. darlingi mosquitoes. A panel of cytokines at the time of mosquito infection was assessed in patient sera and levels compared among subjects who did and did not infect mosquitoes. Overall, blood from 43 of 99 (43%) subjects led to mosquito infection as shown by oocyst counts. Levels of IL-10, IL-6, TNF-α, and IFN-γ were significantly elevated in vivax infection and normalized 3 weeks later. The anti-inflammatory cytokine IL-10 was significantly higher in nontransmitters compared with top transmitters but was not in TNF-α and IFN-γ. The IL-10 elevation during acute malaria was associated with P. vivax transmission blocking.

Indexed as

Host-Parasite InteractionsInsect VectorsAdolescentAdultAnimalsAnophelesCytokinesFemaleHumansInterferon-gammaInterleukin-10Interleukin-6MalariaMalaria, VivaxMaleMiddle AgedCytokinesInterferon-gammaInterleukin-10Interleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID23478585
PMCPMC3752813
OpenAlexW2144076200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.