ArticleScientific reports2013
Malaria pigment crystals as magnetic micro-rotors: key for high-sensitivity diagnosis.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Performance of a sensitive haemozoin-based malaria diagnostic test validated for vivax malaria diagnosis in Brazilian Amazon.Malaria journal · 2021Trial
- Magneto-optical microscopy platform for quantitative imaging of hemozoin in blood for malaria diagnosis.Biomedical optics express · 2026Article
- Autofluorescence of Red Blood Cells Infected withBiosensors · 2025Article
- Magneto-optical assessment of Plasmodium parasite growth via hemozoin crystal size.Scientific reports · 2024Article
- Next Generation Chemiluminescent Probes for Antimalarial Drug Discovery.ACS infectious diseases · 2024Article
- The Laboratory Diagnosis of Malaria: A Focus on the Diagnostic Assays in Non-Endemic Areas.International journal of molecular sciences · 2024Review
- Reducing data dimension boosts neural network-based stage-specific malaria detection.Scientific reports · 2022Article
- Sensitive detection of Plasmodium vivax malaria by the rotating-crystal magneto-optical method in Thailand.Scientific reports · 2021Article
- An ON-OFF Magneto-Optical Probe of Anisotropic Biofluid Crystals: AIEEE transactions on magnetics · 2021Article
- A Lab-On-chip Tool for Rapid, Quantitative, and Stage-selective Diagnosis of Malaria.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Magneto-optical diagnosis of symptomatic malaria in Papua New Guinea.Nature communications · 2021Article
- Field validation of a magneto-optical detection device (Gazelle) for portable point-of-care Plasmodium vivax diagnosis.PloS one · 2021Article
- Quantitative diffuse optical spectroscopy for noninvasive measurements of the malaria pigment hemozoin.Biomedical optics express · 2020Article
- On-Chip Selective Capture and Detection of Magnetic Fingerprints of Malaria.Sensors (Basel, Switzerland) · 2020Article
- Rapid and quantitative antimalarial drug efficacy testing via the magneto-optical detection of hemozoin.Scientific reports · 2020Article
- Highly Sensitive and Rapid Characterization of the Development of Synchronized Blood Stage Malaria Parasites Via Magneto-Optical Hemozoin Quantification.Biomolecules · 2019Article
- Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis.Nature communications · 2019Article
- Diamond Magnetic Microscopy of Malarial Hemozoin Nanocrystals.Physical review applied · 2019Article
- Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.Chemical reviews · 2019Review
- Growth of Plasmodium falciparum in response to a rotating magnetic field.Malaria journal · 2018Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The need to develop new methods for the high-sensitivity diagnosis of malaria has initiated a global activity in medical and interdisciplinary sciences. Most of the diverse variety of emerging techniques are based on research-grade instruments, sophisticated reagent-based assays or rely on expertise. Here, we suggest an alternative optical methodology with an easy-to-use and cost-effective instrumentation based on unique properties of malaria pigment reported previously and determined quantitatively in the present study. Malaria pigment, also called hemozoin, is an insoluble microcrystalline form of heme. These crystallites show remarkable magnetic and optical anisotropy distinctly from any other components of blood. As a consequence, they can simultaneously act as magnetically driven micro-rotors and spinning polarizers in suspensions. These properties can gain importance not only in malaria diagnosis and therapies, where hemozoin is considered as drug target or immune modulator, but also in the magnetic manipulation of cells and tissues on the microscopic scale.
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