Evidence map›Paper›PMID 23478337›Full record

ReviewEMBO reports2013

The dynamics of gut-associated microbial communities during inflammation.

Sebastian E Winter, Christopher A Lopez, Andreas J Bäumler

Abstract readReview
In one paragraph

Review in EMBO reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

202 citing papers in PubMed.

  1. Trial
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  3. Trial
  4. Review
  5. Article
  6. Review
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  9. ZnbioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Periplasmic detoxification of urate hydroperoxide underpinsbioRxiv : the preprint server for biology · 2026
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Revisiting the gene loss of respiratory requirements for Salmonella Typhimurium and Salmonella Enteritidis in the chicken infection model.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025
    Article
  20. Article

142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sebastian E WinterDepartment of Medical Microbiology & Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA.
Christopher A Lopez
Andreas J Bäumler

Funding

Virulence Factors of SalmonellaR01AI044170 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI BAUMLER, ANDREAS J · 1999 to 2022
$8.5M
Microbiota Outgrowth by SalmonellaR01AI096528 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2011 to 2025
$6.1M
Animal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3M
Host Interactions of Salmonella typhimuriumR01AI076246 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ADAMS, LESLIE GARRY, BAUMLER, ANDREAS J · 2009 to 2013
$2.7M
Adherent Invasive E. coli and colitisR21AI107393 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMLER, ANDREAS J · 2013 to 2014
$410k
NIAID NIH HHS AI044170NIAID NIH HHS AI060555NIAID NIH HHS AI076246NIAID NIH HHS AI096528NIAID NIH HHS R01 AI044170NIAID NIH HHS R01 AI076246NIAID NIH HHS R01 AI096528NIAID NIH HHS R21 AI107393NIAID NIH HHS T32 AI060555
6 · The paper itself

Abstract

Our intestine is host to a large microbial community (microbiota) that educates the immune system and confers niche protection. Profiling of the gut-associated microbial community reveals a dominance of obligate anaerobic bacteria in healthy individuals. However, intestinal inflammation is associated with a disturbance of the microbiota-known as dysbiosis-that often includes an increased prevalence of facultative anaerobic bacteria. This group contains potentially harmful bacterial species, the bloom of which can further exacerbate inflammation. Here, we review the mechanisms that generate changes in the microbial community structure during inflammation. One emerging concept is that electron acceptors generated as by-products of the host inflammatory response feed facultative anaerobic bacteria selectively, thereby increasing their prevalence within the community. This new paradigm has broad implications for understanding dysbiosis during gut inflammation and identifies potential targets for intervention strategies.

Indexed as

AnimalsEnterobacteriaceaeGastroenteritisGastrointestinal TractHost-Pathogen InteractionsHumansMetagenomeVirulence FactorsVirulence Factors

Identifiers

PMID23478337
PMCPMC3615657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.