ArticleEnvironmental health perspectives2013
Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Improved Methodology for Evaluating Nanomedicine Antibacterial Properties in Biological Fluids.ACS pharmacology & translational science · 2024Article
- Respiratory and physical health consequences in older adults in a high-risk volcanic area: Comparison of two rural villages.PloS one · 2024Article
- Article
- Assessment of the potential respiratory hazard of volcanic ash from future Icelandic eruptions: a study of archived basaltic to rhyolitic ash samples.Environmental health : a global access science source · 2017Article
- Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid.Environmental health perspectives · 2017Article
- Volcanic Ash Activates the NLRP3 Inflammasome in Murine and Human Macrophages.Frontiers in immunology · 2017Article
- Combined exposure of diesel exhaust particles and respirable Soufrière Hills volcanic ash causes a (pro-)inflammatory response in an in vitro multicellular epithelial tissue barrier model.Particle and fibre toxicology · 2016Article
- Emergency hospital visits in association with volcanic ash, dust storms and other sources of ambient particles: a time-series study in Reykjavík, Iceland.International journal of environmental research and public health · 2015Article
- Iron oxide nanoparticles induceEnvironmental science. Nano · 2014Article
- Volcanic ash and the respiratory immune system: possible mechanisms behind reported infections.Environmental health perspectives · 2013Article
- Volcanic air pollution over the Island of Hawai'i: Emissions, dispersal, and composition. Association with respiratory symptoms and lung function in Hawai'i Island school children.Environment internationalArticle
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundOn 20 March 2010, the Icelandic volcano Eyjafjallajökull erupted for the first time in 190 years. Despite many epidemiological reports showing effects of volcanic ash on the respiratory system, there are limited data evaluating cellular mechanisms involved in the response to ash. Epidemiological studies have observed an increase in respiratory infections in subjects and populations exposed to volcanic eruptions.
methodsWe physicochemically characterized volcanic ash, finding various sizes of particles, as well as the presence of several transition metals, including iron. We examined the effect of Eyjafjallajökull ash on primary rat alveolar epithelial cells and human airway epithelial cells (20-100 µg/cm(2)), primary rat and human alveolar macrophages (5-20 µg/cm(2)), and Pseudomonas aeruginosa (PAO1) growth (3 µg/104 bacteria).
resultsVolcanic ash had minimal effect on alveolar and airway epithelial cell integrity. In alveolar macrophages, volcanic ash disrupted pathogen-killing and inflammatory responses. In in vitro bacterial growth models, volcanic ash increased bacterial replication and decreased bacterial killing by antimicrobial peptides.
conclusionsThese results provide potential biological plausibility for epidemiological data that show an association between air pollution exposure and the development of respiratory infections. These data suggest that volcanic ash exposure, while not seriously compromising lung cell function, may be able to impair innate immunity responses in exposed individuals.
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