ReviewNature reviews. Cardiology2013
The roles of senescence and telomere shortening in cardiovascular disease.
Review in Nature reviews. Cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
167 citing papers in PubMed, 3 syntheses or guidelines pooled it, 371 citations in OpenAlex.
- The impact of hypertension on leukocyte telomere length: a systematic review and meta-analysis of human studies.Journal of human hypertension · 2017Pooled it
- Telomere length and health outcomes: A two-sample genetic instrumental variables analysis.Experimental gerontology · 2016Pooled it
- 8-hydroxy-2'-deoxyguanosine and cardiovascular disease: a systematic review.Current atherosclerosis reports · 2014Pooled it
- Trial
- Reverse causal relationship between periodontitis and shortened telomere length: Bidirectional two-sample Mendelian random analysis.Frontiers in immunology · 2022Trial
- Leukocyte telomere length and left ventricular function after acute ST-elevation myocardial infarction: data from the glycometabolic intervention as adjunct to primary coronary intervention in ST elevation myocardial infarction (GIPS-III) trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Mechanisms of Doxorubicin-Induced Cardiac Senescence and Potential Therapeutic Strategies.Biomolecules · 2026Review
- Leukocyte telomere length and risk of heart failure with preserved ejection fraction in high-risk Chinese patients with hypertension under 65 years.GeroScience · 2026Observational
- Extracurricular physical activity and telomere length in childhood: findings from the INMA study.Pediatric research · 2026Article
- Telomere length dynamics do not predict subclinical atherosclerosis progression over a six-year period.GeroScience · 2026Article
- Exposure of endothelial cells to doxorubicin inhibits extracellular matrix production by dermal fibroblasts in a paracrine manner.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Optimized primer and model improve precision of X chromosome telomere length determination in the Han population.iScience · 2026Article
- Transcriptional regulation in cardiovascular aging.Frontiers in cardiovascular medicine · 2026Review
- Aging and coronary artery calcification: a Mendelian randomization study.Archives of medical science : AMS · 2026Article
- The novel nutritional metabolic risk index and established triglyceride-glucose indices in type 2 diabetes: modifying role of biological aging assessed by telomere length.Frontiers in nutrition · 2026Article
- Causal relevance of clonal haematopoiesis with cardiac disease and adverse remodelling: a Mendelian randomisation study.Open heart · 2025Article
- The role of cellular senescence in cardiovascular disease.Cell death discovery · 2025Review
- Impact of night shift work on telomere length and epigenetic age in older workers.Journal of occupational medicine and toxicology (London, England) · 2025Article
- Association of Hypertension With Telomere Length, Considering Non-Genetic and Genetic Factors, in Middle-Aged Koreans.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Relationship of Ageing to Insulin Resistance and Atherosclerosis.Metabolites · 2025Review
107 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular senescence, defined as arrest during the cell cycle (G₀), is involved in the complex process of the biological ageing of tissues, organs, and organisms. Senescence is driven by many factors including oxidative stress, the DNA damage and repair response, inflammation, mitogenic signals, and telomere shortening. Telomeres are shortened by each cell division until a critical length is reached and dysfunction ensues. DNA-repair pathways are then recruited and cells enter senescence, losing their capacity to proliferate. In addition to cell division, factors causing telomere shortening include DNA damage, inflammation, and oxidative stress. Both cardiovascular risk factors and common cardiovascular diseases, such as atherosclerosis, heart failure, and hypertension, are associated with short leucocyte telomeres, but causality remains undetermined. Telomere length does not satisfy strict criteria for being a biomarker of ageing, but adds predictive power to that of chronological age, and can be considered a marker of cardiovascular ageing. The 'senescence-associated secretory phenotype' of senescent cells exerts a wide range of autocrine and paracrine activities aimed at tissue repair, but which also fuel degenerative and proliferative alterations that contribute to cardiovascular disease. In this Review, the relationship between telomere shortening, senescence, and cardiovascular disease is discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.