ReviewCurrent opinion in cell biology2013
Imprinted silencing is extended over broad chromosomal domains in mouse extra-embryonic lineages.
Review in Current opinion in cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- ZFP57 dictates allelic expression switch of target imprinted genes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Allelome.PRO, a pipeline to define allele-specific genomic features from high-throughput sequencing data.Nucleic acids research · 2015Article
- Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain.eLife · 2015Article
- Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern.Developmental biology · 2015Article
- What does genetics tell us about imprinting and the placenta connection?Cellular and molecular life sciences : CMLS · 2015Review
- Long noncoding RNAs: an emerging link between gene regulation and nuclear organization.Trends in cell biology · 2014Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Gene silencing in imprinted gene clusters is established by an epigenetic initiator that is often a long non-coding (lnc) RNA. The clustered organization of known imprinted genes indicates that the initiator extends imprinted silencing over broader chromosomal domains in extra-embryonic lineages compared to the embryo. We propose that extension of imprinted gene clusters may result from known epigenetic differences between extra-embryonic and embryonic lineages that alter the behavior of epigenetic initiators. New RNA sequencing technology will enable the full extent of imprinted silencing in embryonic and extra-embryonic lineages to be defined, but appropriate analysis and cell systems are required, which we define here based on a review of recent studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.