ArticleThe Journal of physiology2013
Contribution of sympathetic activation to coronary vasodilatation during the cold pressor test in healthy men: effect of ageing.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Beta-1 vs. beta-2 adrenergic control of coronary blood flow during isometric handgrip exercise in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Brain‑heart axis: Neurostimulation techniques in ischemic heart disease (Review).International journal of molecular medicine · 2025Review
- Hemodynamic responses to the cold pressor test in individuals with metabolic syndrome: a case-control study in a multiracial sample of adults.Journal of human hypertension · 2024Article
- Impaired vascular function among young users of anabolic-androgenic steroids.Scientific reports · 2024Article
- Contrast-enhanced ultrasonography reveals a lower cortical perfusion and a decreased renal flow reserve in hypertensive patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Effects of alpha-adrenergic receptor blockade on coronary circulation in postmenopausal women.European journal of applied physiology · 2023Article
- Sympathetic control of the coronary circulation during trigeminal nerve stimulation in humans.European journal of applied physiology · 2023Article
- Vascular Function, Systemic Inflammation, and Coagulation Activation 18 Months after COVID-19 Infection: An Observational Cohort Study.Journal of clinical medicine · 2023Article
- Sodium nitrate supplementation improves blood pressure reactivity in patients with peripheral artery disease.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2022Article
- Attenuated Cardiovascular Responses to the Cold Pressor Test in Concussed Collegiate Athletes.Journal of athletic training · 2020Article
- Effect of sympathetic autonomic stress from the cold pressor test on left ventricular function in young healthy adults.Physiological reports · 2019Article
- Similarity between carotid and coronary artery responses to sympathetic stimulation and the role of αJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Deleterious Effects of Cold Air Inhalation on Coronary Physiological Indices in Patients With Obstructive Coronary Artery Disease.Journal of the American Heart Association · 2018Article
- Cardiovascular diseases, cold exposure and exercise.Temperature (Austin, Tex.) · 2018Review
- Baseline aortic pulse wave velocity is associated with central and peripheral pressor responses during the cold pressor test in healthy subjects.Physiological reports · 2017Article
- Effect of adrenergic agonists on coronary blood flow: a laboratory study in healthy volunteers.Physiological reports · 2016Article
- β2-adrenergic stress evaluation of coronary endothelial-dependent vasodilator function in mice using (11)C-acetate micro-PET imaging of myocardial blood flow and oxidative metabolism.EJNMMI research · 2014Article
- β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men.American journal of physiology. Heart and circulatory physiology · 2014Article
- Coronary responses to cold air inhalation following afferent and efferent blockade.American journal of physiology. Heart and circulatory physiology · 2014Article
- Altered coronary endothelial function in young smokers detected by magnetic resonance assessment of myocardial blood flow during the cold pressor test.The international journal of cardiovascular imaging · 2014Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The sympathetic nervous system is an important regulator of coronary blood flow. The cold pressor test (CPT) is a powerful sympathoexcitatory stressor. We tested the hypotheses that: (1) CPT-induced sympathetic activation elicits coronary vasodilatation in young adults that is impaired with advancing age and (2) combined α- and β-adrenergic blockade diminishes/abolishes these age-related differences. Vascular responses of the left anterior descending artery to the CPT were determined by transthoracic Doppler echocardiography before (pre-blockade) and during (post-blockade) systemic co-administration of α- and β-adrenergic antagonists in young (n = 9; 26 ± 1 years old, mean ± SEM) and older healthy men (n = 9; 66 ± 2 years old). Coronary vascular resistance (CVR; mean arterial pressure/coronary blood velocity) was used as an index of vascular tone. CPT decreased CVR (i.e. coronary vasodilatation occurred) in young ( -33 ± 6%), but not older men ( -3 ± 4%; P < 0.05 vs. young) pre-blockade. Adrenergic blockade abolished CPT-induced coronary vasodilatation in young men ( -33 ± 6% vs. 0 ± 6%, pre-blockade vs. post-blockade, respectively; P < 0.05) such that responses post-blockade mirrored those of older men ( -3 ± 4% vs. 8 ± 9%; both P > 0.05 compared to young pre-blockade). Impaired CPT-induced coronary vasodilatation could not be explained by a reduced stimulus for vasodilatation as group and condition effects persisted when CVR responses were expressed relative to myocardial oxygen demand (rate-pressure product). These data indicate that the normal coronary vascular response to sympathetic activation in young men is pronounced vasodilatation and this effect is lost with age as the result of an adrenergic mechanism. These findings may help explain how acute sympathoexcitation may precipitate angina and coronary ischaemic events, particularly in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.