Evidence map›Paper›PMID 23478096›Full record

SynthesisHypertension (Dallas, Tex. : 1979)2013

Masked hypertension in diabetes mellitus: treatment implications for clinical practice.

Stanley S Franklin, Lutgarde Thijs, Yan Li, Tine W Hansen, José Boggia, Yanping Liu, Kei Asayama, Kristina Björklund-Bodegård, Takayoshi Ohkubo, Jørgen Jeppesen and 18 more

Abstract readComparative StudyMeta-AnalysisMulticenter Study
In one paragraph

Synthesis in Hypertension (Dallas, Tex. : 1979), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Prognostic Value of Masked Uncontrolled Hypertension.Hypertension (Dallas, Tex. : 1979) · 2018
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Time in target range of systolic blood pressure and eGFR slope in patients with type 2 diabetes.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. What did we learn from the International Databases on Ambulatory and Home Blood Pressure in Relation to Cardiovascular Outcome?Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Stanley S FranklinHeart Disease Prevention Program, Division of Cardiology, School of Medicine, University of California, Irvine, California, USA.
Lutgarde Thijs
Yan Li
Tine W Hansen
José Boggia
Yanping Liu
Kei Asayama
Kristina Björklund-Bodegård
Takayoshi Ohkubo
Jørgen Jeppesen
Christian Torp-Pedersen
Eamon Dolan
Tatiana Kuznetsova
Katarzyna Stolarz-Skrzypek
Valérie Tikhonoff
Sofia Malyutina
Edoardo Casiglia
Yuri Nikitin
Lars Lind
Edgardo Sandoya
Kalina Kawecka-Jaszcz
Jan Filipovsky
Yutaka Imai
Jiguang Wang
Hans Ibsen
Eoin O'Brien
Jan A Staessen
International Database on Ambulatory blood pressure in Relation to Cardiovascular Outcomes Investigators

Funding

European Research Council 294713
6 · The paper itself

Abstract

Although distinguishing features of masked hypertension in diabetics are well known, the significance of antihypertensive treatment on clinical practice decisions has not been fully explored. We analyzed 9691 subjects from the population-based 11-country International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes. Prevalence of masked hypertension in untreated normotensive participants was higher (P<0.0001) among 229 diabetics (29.3%, n=67) than among 5486 nondiabetics (18.8%, n=1031). Over a median of 11.0 years of follow-up, the adjusted risk for a composite cardiovascular end point in untreated diabetic-masked hypertensives tended to be higher than in normotensives (hazard rate [HR], 1.96; 95% confidence interval [CI], 0.97-3.97; P=0.059), similar to untreated stage 1 hypertensives (HR, 1.07; CI, 0.58-1.98; P=0.82), but less than stage 2 hypertensives (HR, 0.53; CI, 0.29-0.99; P=0.048). In contrast, cardiovascular risk was not significantly different in antihypertensive-treated diabetic-masked hypertensives, as compared with the normotensive comparator group (HR, 1.13; CI, 0.54-2.35; P=0.75), stage 1 hypertensives (HR, 0.91; CI, 0.49-1.69; P=0.76), and stage 2 hypertensives (HR, 0.65; CI, 0.35-1.20; P=0.17). In the untreated diabetic-masked hypertensive population, mean conventional systolic/diastolic blood pressure was 129.2 ± 8.0/76.0 ± 7.3 mm Hg, and mean daytime systolic/diastolic blood pressure 141.5 ± 9.1/83.7 ± 6.5 mm Hg. In conclusion, masked hypertension occurred in 29% of untreated diabetics, had comparable cardiovascular risk as stage 1 hypertension, and would require considerable reduction in conventional blood pressure to reach daytime ambulatory treatment goal. Importantly, many hypertensive diabetics when receiving antihypertensive therapy can present with normalized conventional and elevated ambulatory blood pressure that mimics masked hypertension.

Indexed as

Practice Patterns, Physicians'AdultAgedAntihypertensive AgentsBlood PressureBlood Pressure DeterminationCardiovascular DiseasesCohort StudiesComorbidityDiabetes MellitusFemaleFollow-Up StudiesHumansInternational CooperationMaleMasked HypertensionAntihypertensive Agents

Identifiers

PMID23478096
PMCPMC3631136

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.