ArticleParkinson's disease2013
High prevalence of gastroesophageal reflux disease in Parkinson's disease: a questionnaire-based study.
Article in Parkinson's disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Consensus expert recommendations for management of dysphagia during hospital admission in Parkinson's disease.Journal of Parkinson's disease · 2026Review
- Outcomes Following Constipation Treatments Between Parkinson's Disease and Non-Parkinson's Disease Patients Evaluated by the Constipation Scoring System.Parkinson's disease · 2026Article
- "Coordination of Anle138b to Silver Results in Selective Reduction of a C-terminal truncated Alpha-synuclein Protein and Increased Aggregate Size."bioRxiv : the preprint server for biology · 2025Article
- Upper Gastrointestinal Mucosal Damage and Subsequent Risk of Parkinson Disease.JAMA network open · 2024Article
- Parkinson's disease and the risk of gastrointestinal cancers: a two-sample Mendelian randomization study.Journal of gastrointestinal oncology · 2024Article
- Differentially expressed genes of esophageal tissue in male acute and chronic sleep deprivation mice.Genes, brain, and behavior · 2024Article
- Chinese expert consensus on diagnosis and management of gastroesophageal reflux disease in the elderly (2023).Aging medicine (Milton (N.S.W)) · 2024Article
- Gastrointestinal Dysfunction in Parkinson's Disease: Neuro-Gastroenterology Perspectives on a Multifaceted Problem.Journal of movement disorders · 2023Article
- Characterization of Aspirated Duodenal Fluids from Parkinson's Disease Patients.Pharmaceutics · 2023Article
- Observational
- The Impact of Non-dopaminergic Medication on Quality of Life in Parkinson's Disease.Clinical drug investigation · 2021Article
- Circulating cell-free mitochondrial DNA levels in Parkinson's disease are influenced by treatment.Molecular neurodegeneration · 2020Article
- Naturopathic Treatment of Gastrointestinal Dysfunction in the Setting of Parkinson's Disease.Integrative medicine (Encinitas, Calif.) · 2018Article
- Bioavailability of a dexlansoprazole delayed-release orally disintegrating tablet: effects of food and mode of administration.Clinical and experimental gastroenterology · 2017Article
- Gastrointestinal dysfunction in idiopathic Parkinsonism: A narrative review.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
- Parkinson's disease between internal medicine and neurology.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study is to investigate the frequency and clinical features of gastroesophageal reflex disease (GERD) in Parkinson's disease (PD). Consecutively recruited PD patients and controls were questioned about heartburn and GERD with a questionnaire. In PD patients, disease duration and severity, quality of life, and nonmotor symptoms were also examined and then the clinical features of GERD were analyzed. A total of 102 patients and 49 controls were enrolled and 21 patients and 4 controls had heartburn, significantly frequent in PD. The prevalence rate of GERD was 26.5% in PD and the odds ratio was 4.05. Heartburn, bent forward flexion, and wearing-off phenomenon were frequent, and scores of UPDRS, total and part II, PD questionnaire-39, and nonmotor symptom scale were significantly higher in PD patients with GERD than without GERD. Multiple logistic regression analysis revealed statistical significance in UPDRS part II and nonmotor symptom scale. This study suggests that GERD is prevalent in PD. Deterioration of daily living activities and other nonmotor symptoms can imply the presence of GERD. Because clinical symptoms of GERD are usually treatable, the management can improve the patient's quality of life. Increased attention should be given to detect GERD in PD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.