ArticleEvidence-based complementary and alternative medicine : eCAM2013
Tualang honey promotes apoptotic cell death induced by tamoxifen in breast cancer cell lines.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Medicinal activities of Tualang honey: a systematic review.BMC complementary medicine and therapies · 2024Pooled it
- Recent Progress on Polyphenols of Malaysian Honey and Their Molecular Mechanism Pathways in Cancer-A Comprehensive Review.International journal of molecular sciences · 2026Review
- Antiproliferative and apoptotic effects of Pervari honey on SH-SY5Y neuroblastoma cells.Medical oncology (Northwood, London, England) · 2025Article
- Article
- Evaluation of Therapeutic Activity of Tualang Honey on Oral Cancer: Histopathological Study.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Review on role of honey in disease prevention and treatment through modulation of biological activities.Open life sciences · 2025Review
- Cancer Patients' Use of Apitherapy as Supportive Care: An Exploratory Study.The Eurasian journal of medicine · 2024Article
- Differential Apoptotic Effects of Bee Product Mixtures on Normal and Cancer Hepatic Cells.Antioxidants (Basel, Switzerland) · 2023Article
- Honey: A Promising Therapeutic Supplement for the Prevention and Management of Osteoporosis and Breast Cancer.Antioxidants (Basel, Switzerland) · 2023Review
- Physicochemical Characteristics and Bioactive Compounds of Different Types of Honey and Their Biological and Therapeutic Properties: A Comprehensive Review.Antibiotics (Basel, Switzerland) · 2023Review
- Uses of Natural Honey in Cancer: An Updated Review.Advanced pharmaceutical bulletin · 2022Review
- Monofloral Honeys as a Potential Source of Natural Antioxidants, Minerals and Medicine.Antioxidants (Basel, Switzerland) · 2021Review
- Physicochemical and Medicinal Properties of Tualang, Gelam and Kelulut Honeys: A Comprehensive Review.Nutrients · 2021Review
- Antioxidant or pro-oxidant and glutathione transferase P1-1 inhibiting activities for Tamarindus indica seeds and their cytotoxic effect on MCF-7 cancer cell line.Journal, genetic engineering & biotechnology · 2020Article
- Chemical Analysis and Cytotoxic and Cytostatic Effects of Twelve Honey Samples Collected from Different Regions in Morocco and Palestine.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Zeolite X from coal fly ash inhibits proliferation of human breast cancer cell lines (MCF-7) via induction of S phase arrest and apoptosis.Molecular biology reports · 2018Article
- Honey and Diabetes: The Importance of Natural Simple Sugars in Diet for Preventing and Treating Different Type of Diabetes.Oxidative medicine and cellular longevity · 2018Review
- Honey as a Complementary Medicine.Integrative medicine insights · 2017Review
- Honey and Cancer: Current Status and Future Directions.Diseases (Basel, Switzerland) · 2016Review
- Novel Insights into the Health Importance of Natural Honey.The Malaysian journal of medical sciences : MJMS · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tualang honey (TH) is rich in flavonoids and phenolic acids and has significant anticancer activity against breast cancer cells comparable to the effect of tamoxifen (TAM), in vitro. The current study evaluated the effects of TH when used in combination with TAM on MCF-7 and MDA-MB-231 cells. We observed that TH promoted the anticancer activity of TAM in both the estrogen receptor-(ER-)responsive and ER-nonresponsive human breast cancer cell lines. Flow cytometric analyses indicated accelerated apoptosis especially in MDA-MB-231 cells and with the involvement of caspase-3/7, -8 and -9 activation as shown by fluorescence microscopy. Depolarization of the mitochondrial membrane was also increased in both cell lines when TH was used in combination with TAM compared to TAM treatment alone. TH may therefore be a potential adjuvant to be used with TAM for reducing the dose of TAM, hence, reducing TAM-induced adverse effects.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.