ArticleTheScientificWorldJournal2013
Regulation of recombination between gtfB/gtfC genes in Streptococcus mutans by recombinase A.
Article in TheScientificWorldJournal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
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- Anti-Infection of Oral Microorganisms from Herbal Medicine ofDrug design, development and therapy · 2024Review
- Phytochemical Profile of Antibacterial Agents from Red Betel Leaf (Molecules (Basel, Switzerland) · 2022Review
- Cnm ofFrontiers in cellular and infection microbiology · 2022Article
- Effects of Rhein-8-O-β-D-glucopyranoside on the Biofilm Formation of Streptococcus mutans.Current microbiology · 2021Article
- [Link between sortase A function and cariogenicity of Streptococcus mutans: a preliminary metabolomics analysis].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018Article
- Farnesol inhibits development of caries by augmenting oxygen sensitivity and suppressing virulence-associated gene expression inStreptococcus mutans.Journal of biomedical research · 2017Article
- Mechanistic, genomic and proteomic study on the effects of BisGMA-derived biodegradation product on cariogenic bacteria.Dental materials : official publication of the Academy of Dental Materials · 2017Article
- Triethylene Glycol Up-Regulates Virulence-Associated Genes and Proteins in Streptococcus mutans.PloS one · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus mutans produces 3 types of glucosyltransferases (GTFs), whose cooperative action is essential for cellular adhesion. The recombinase A (RecA) protein is required for homologous recombination. In our previous study, we isolated several strains with a smooth colony morphology and low GTF activity, characteristics speculated to be derived from the GTF fusions. The purpose of the present study was to investigate the mechanism of those fusions. S. mutans strain MT8148 was grown in the presence of recombinant RecA (rRecA) protein, after which smooth colonies were isolated. The biological functions and sequences of the gtfB and gtfC genes of this as well as other clinical strains were determined. The sucrose-dependent adherence rates of those strains were reduced as compared to that of MT8148. Determination of the sequences of the gtfB and gtfC genes showed that an approximately 3500 bp region was deleted from the area between them. Furthermore, expression of the recA gene was elevated in those strains as compared to MT8148. These results suggest that RecA has an important role in fusions of gtfB and gtfC genes, leading to alteration of colony morphology and reduction in sucrose-dependent adhesion.
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