ArticleEpilepsy currents2012
AED Treatment Through Different Ages: As Our Brains Change, Should Our Drug Choices Also?
Article in Epilepsy currents, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- Beta-band power modulation in the human amygdala differentiates between go/no-go responses in an arm-reaching task.Journal of neural engineering · 2024Article
- A review of cognitive and behavioral outcomes of Brivaracetam.The Kaohsiung journal of medical sciences · 2023Review
- Anti-Epileptic Drugs in Geriatric Neurosurgery: A Review of 669 Neurosurgical Cases.Journal of epilepsy research · 2022Article
- The Kappa Opioid Receptor System in Temporal Lobe Epilepsy.Handbook of experimental pharmacology · 2022Article
- Acute symptomatic seizures and status epilepticus in older adults: A narrative review focusing on management and outcomes.Frontiers in neurology · 2022Review
- Molecular Docking Studies on Anticonvulsant Enaminones Inhibiting Voltage-Gated Sodium Channels.Open journal of physical chemistry · 2019Article
- Prediction Tools for Psychiatric Adverse Effects After Levetiracetam Prescription.JAMA neurology · 2019Article
- Seizure in Alzheimer's Disease: An Underestimated Phenomenon.American journal of Alzheimer's disease and other dementias · 2019Review
- 6 Hz Active Anticonvulsant Fluorinated N-Benzamide Enaminones and Their Inhibitory Neuronal Activity.International journal of environmental research and public health · 2018Article
- Epilepsy in the elderly: Special considerations and challenges.Annals of Indian Academy of Neurology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patient age can impact selection of the optimal antiepileptic drug for a number of reasons. Changes in brain physiology from neonate to elderly, as well as changes in underlying etiologies of epilepsy, could potentially affect the ability of different drugs to control seizures. Unfortunately, much of this is speculative, as good studies demonstrating differences in efficacy across age ranges do not exist. Beyond the issue of efficacy, certain drugs may be more or less appropriate at different ages because of differing pharmacokinetics, including changes in hepatic metabolism, absorption, and elimination. Lack of appropriate drug formulations (such as liquid forms) may be a barrier to using drugs in the very young. Finally, some serious adverse events are seen either exclusively or preferentially at different ages.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.