ArticleProceedings of the National Academy of Sciences of the United States of America2013
High-resolution metabolic mapping of cell types in plant roots.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 146 citations in OpenAlex.
- Artificial soil (ArtSoil): Recreating soil conditions in synthetic plant growth media.The Plant journal : for cell and molecular biology · 2026Article
- A plastidic starch biosynthetic pathway defines columella-specific carbon metabolism in rice root tips.Frontiers in plant science · 2026Article
- Not to be overlooked: dipeptides and their role in plant stress resilience.Journal of experimental botany · 2025Review
- Exploring the untapped potential of single-cell and spatial omics in plant biology.The New phytologist · 2025Review
- Systems Biology Applications in Revealing Plant Defense Mechanisms in Disease Triangle.International journal of molecular sciences · 2025Review
- Differential root zone secretions and the role of root border cells in rhizosphere manipulation.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2025Review
- Imaging Metabolic Flow of Water in Plants with Isotope-Traced Stimulated Raman Scattering Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Plant Heterotrophic Cultures: No Food, No Growth.Plants (Basel, Switzerland) · 2024Review
- The proteome landscape of the root cap reveals a role for the jacalin-associated lectin JAL10 in the salt-induced endoplasmic reticulum stress pathway.Plant communications · 2023Article
- Can plant hormonomics be built on simple analysis? A review.Plant methods · 2023Review
- Advances in single-cell metabolomics to unravel cellular heterogeneity in plant biology.Plant physiology · 2023Review
- Cell type-specific mapping of ion distribution in Arabidopsis thaliana roots.Nature communications · 2023Article
- Chemical imaging reveals diverse functions of tricarboxylic acid metabolites in root growth and development.Nature communications · 2023Article
- ASSVd infection inhibits the vegetative growth of apple trees by affecting leaf metabolism.Frontiers in plant science · 2023Article
- Lipid desaturation regulates the balance between self-renewal and differentiation in mouse blastocyst-derived stem cells.Cell death & disease · 2022Article
- Development specifies, diversifies and empowers root immunity.EMBO reports · 2022Review
- Past accomplishments and future challenges of the multi-omics characterization of leaf growth.Plant physiology · 2022Review
- Identification of Potential Genes Encoding Protein Transporters inLife (Basel, Switzerland) · 2022Article
- Responsiveness of Aromatoleum aromaticum EbN1Applied and environmental microbiology · 2021Article
- Tissue-specific signatures of metabolites and proteins in asparagus roots and exudates.Horticulture research · 2021Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolite composition offers a powerful tool for understanding gene function and regulatory processes. However, metabolomics studies on multicellular organisms have thus far been performed primarily on whole organisms, organs, or cell lines, losing information about individual cell types within a tissue. With the goal of profiling metabolite content in different cell populations within an organ, we used FACS to dissect GFP-marked cells from Arabidopsis roots for metabolomics analysis. Here, we present the metabolic profiles obtained from five GFP-tagged lines representing core cell types in the root. Fifty metabolites were putatively identified, with the most prominent groups being glucosinolates, phenylpropanoids, and dipeptides, the latter of which is not yet explored in roots. The mRNA expression of enzymes or regulators in the corresponding biosynthetic pathways was compared with the relative metabolite abundance. Positive correlations suggest that the rate-limiting steps in biosynthesis of glucosinolates in the root are oxidative modifications of side chains. The current study presents a work flow for metabolomics analyses of cell-type populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.