ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2013
Safe direct current stimulation to expand capabilities of neural prostheses.
Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The assistive gait devices and their implementation in activities of daily living for patients with neuromuscular disease: A systematic review and meta-analysis.Journal of neuromuscular diseases · 2026Pooled it
- Ionic Direct Current Enables Millimeter- and Millisecond-Scale Cortical Gain Control in vivo.bioRxiv : the preprint server for biology · 2025Article
- Temporal properties of transcutaneous direct current motor conduction block.Journal of neural engineering · 2025Article
- Bioelectronic Direct Current Stimulation at the Transition Between Reversible and Irreversible Charge Transfer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Peripheral direct current reduces naturally evoked nociceptive activity at the spinal cord in rodent models of pain.Journal of neural engineering · 2024Article
- Galvanic vs. pulsatile effects on decision-making networks: reshaping the neural activation landscape.Journal of neural engineering · 2024Article
- Vestibular prosthesis: from basic research to clinics.Frontiers in integrative neuroscience · 2023Review
- A prosthesis utilizing natural vestibular encoding strategies improves sensorimotor performance in monkeys.PLoS biology · 2022Article
- Ionic transistor using ion exchange membranes.Lab on a chip · 2022Article
- A Hydrogel-Based Microfluidic Nerve Cuff for Neuromodulation of Peripheral Nerves.Micromachines · 2021Article
- On-chip ionic current sensor.Applied physics. A, Materials science & processing · 2021Article
- Combining direct current and kilohertz frequency alternating current to mitigate onset activity during electrical nerve block.Journal of neural engineering · 2021Article
- Article
- Cut wires: The Electrophysiology of Regenerated Tissue.Bioelectronic medicine · 2021Review
- A microfluidic system integrated with shape memory alloy valves for a safe direct current delivery system.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020Article
- Identifying the Role of Block Length in Neural Heat Block to Reduce Temperatures During Infrared Neural Inhibition.Lasers in surgery and medicine · 2020Article
- Effect of Intraoperative Electrical Stimulation on Recovery after Rat Sciatic Nerve Isograft Repair.Neurotrauma reports · 2020Article
- Electrochemistry of Graphene Nanoplatelets Printed Electrodes for Cortical Direct Current Stimulation.Frontiers in neuroscience · 2020Article
- Ionic direct current modulation evokes spike-rate adaptation in the vestibular periphery.Scientific reports · 2019Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
While effective in treating some neurological disorders, neuroelectric prostheses are fundamentally limited because they must employ charge-balanced stimuli to avoid evolution of irreversible electrochemical reactions and their byproducts at the interface between metal electrodes and body fluids. Charge-balancing is typically achieved by using brief biphasic alternating current (AC) pulses, which typically excite nearby neural tissues but cannot efficiently inhibit them. In contrast, direct current (DC) applied via a metal electrode in contact with body fluids can excite, inhibit and modulate sensitivity of neurons; however, chronic DC stimulation is incompatible with biology because it violates charge injection limits that have long been considered unavoidable. In this paper, we describe the design and fabrication of a Safe DC Stimulator (SDCS) that overcomes this constraint. The SCDS drives DC ionic current into target tissue via salt-bridge micropipette electrodes by switching valves in phase with AC square waves applied to metal electrodes contained within the device. This approach achieves DC ionic flow through tissue while still adhering to charge-balancing constraints at each electrode-saline interface. We show the SDCS's ability to both inhibit and excite neural activity to achieve improved dynamic range during prosthetic stimulation of the vestibular part of the inner ear in chinchillas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.