ArticleArchives of disease in childhood2013
UK vaccination schedule: persistence of immunity to hepatitis B in children vaccinated after perinatal exposure.
Article in Archives of disease in childhood, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00873652 (An Observational Study of Children Immunised in Infancy Against Hepatitis B Virus, Evaluating the Persistence of Immunity and the Immune Response to a Scheduled Booster Dose of Hepatitis B Vaccine), which is not on this map. Cited by 4 papers.
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An Observational Study of Children Immunised in Infancy Against Hepatitis B Virus, Evaluating the Persistence of Immunity and the Immune Response to a Scheduled Booster Dose of Hepatitis B Vaccine
Who cites it
4 citing papers in PubMed.
- The burden of cirrhosis and other chronic liver diseases due to hepatitis B in children and adolescents: results from global burden of disease study 2019.Frontiers in public health · 2023Article
- Analysis of the positive results and influencing factors of hepatitis B antibody in hospitalized neonates with AgHBs positive mothers.Frontiers in pediatrics · 2022Article
- Article
- Antibody and immune memory persistence post infant hepatitis B vaccination.Patient preference and adherence · 2013Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess persistence of immunity to hepatitis B (HBV) in primary school children vaccinated following perinatal exposure.
designSerological survey.
settingFive UK sites (Berkshire East, Birmingham, Buckinghamshire, Milton Keynes and Oxfordshire).
participantsChildren from 3 years 4 months to 10 years of age (mean age 6.2 years), vaccinated against HBV from birth following perinatal exposure.
interventionsA single booster dose of the paediatric formulation of a recombinant HBV vaccine.
main outcome measuresTitres of antibody against hepatitis B Surface Antigen (anti-HBs) measured immediately before and 21-35 days after the HBV vaccine booster.
resultsPrebooster anti-HBs titres were >10 mIU/ml in 84.6% of children (n=26; 95% CI 65.1 to 95.6%). All children (n=25, 95% CI 86.3 to 100%) had titres >100 mIU/ml after the booster.
conclusionsThis study of antibody persistence among UK children born to hepatitis B infected women, immunised with a 3-dose infant schedule with a toddler booster suggests sustained immunity through early childhood. These data should prompt further studies to address the need for a preschool booster.
trial registrationEudract Number 2008-004785-98.
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