ArticleGenes & development2013
The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1.
Article in Genes & development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Molecular Patho-mechanisms of cervical cancer (MMP1).Annals of medicine and surgery (2012) · 2022Review
- Rab11fip5 regulates telencephalon development via ephrinB1 recycling.Development (Cambridge, England) · 2021Article
- Eph receptors: the bridge linking host and virus.Cellular and molecular life sciences : CMLS · 2020Review
- Getting direction(s): The Eph/ephrin signaling system in cell positioning.Developmental biology · 2019Review
- The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development.Scientific reports · 2018Article
- Asymmetry at cell-cell interfaces direct cell sorting, boundary formation, and tissue morphogenesis.Experimental cell research · 2017Review
- A frog's view of EphrinB signaling.Genesis (New York, N.Y. : 2000) · 2017Review
- Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos.Development (Cambridge, England) · 2016Article
- EphB/ephrinB signaling in cell adhesion and migration.Molecules and cells · 2015Review
- Eph receptors and ephrins: therapeutic opportunities.Annual review of pharmacology and toxicology · 2015Review
- Variable combinations of specific ephrin ligand/Eph receptor pairs control embryonic tissue separation.PLoS biology · 2014Article
- EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activation.The Journal of biological chemistry · 2014Article
- Cell segregation in the vertebrate hindbrain relies on actomyosin cables located at the interhombomeric boundaries.The EMBO journal · 2014Article
- The role of heredity in pterygium development.International journal of ophthalmology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The formation of tissue boundaries is dependent on the cell-cell adhesion/repulsion system that is required for normal morphogenetic processes during development. The Smad ubiquitin regulatory factors (Smurfs) are E3 ubiquitin ligases with established roles in cell growth and differentiation, but whose roles in regulating cell adhesion and migration are just beginning to emerge. Here, we demonstrate that the Smurfs regulate tissue separation at mesoderm/ectoderm boundaries through antagonistic interactions with ephrinB1, an Eph receptor ligand that has a key role in regulating the separation of embryonic germ layers. EphrinB1 is targeted by Smurf2 for degradation; however, a Smurf1 interaction with ephrinB1 prevents the association with Smurf2 and precludes ephrinB1 from ubiquitination and degradation, since it is a substantially weaker substrate for Smurf1. Inhibition of Smurf1 expression in embryonic mesoderm results in loss of ephrinB1-mediated separation of this tissue from the ectoderm, which can be rescued by the coincident inhibition of Smurf2 expression. This system of differential interactions between Smurfs and ephrinB1 regulates the maintenance of tissue boundaries through the control of ephrinB protein levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.