ArticleThe Journal of antimicrobial chemotherapy2013
Risk factors for failure of outpatient parenteral antibiotic therapy (OPAT) in infective endocarditis.
Article in The Journal of antimicrobial chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Quality Indicators for Appropriate Outpatient Parenteral Antimicrobial Therapy in Adults: A Systematic Review and RAND-modified Delphi Procedure.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Pooled it
- Clinical and cost-effectiveness, safety and acceptability ofBMJ open · 2017Pooled it
- Delivery of Outpatient Parenteral Antimicrobial Therapy (OPAT) in an Ever-Changing National Health Service (UK): Benefits, Barriers, and Opportunities.Antibiotics (Basel, Switzerland) · 2025Review
- Current practices and challenges of outpatient parenteral antimicrobial therapy: a narrative review.The Journal of antimicrobial chemotherapy · 2024Review
- Usefulness of Routine Laboratory Tests for Follow up of Patients Receiving Outpatient Parenteral Antimicrobial Therapy Run by Infectious Diseases Fellows.Antibiotics (Basel, Switzerland) · 2023Article
- Impact of a Pharmacist-Managed Outpatient Parenteral Antimicrobial Therapy (OPAT) Service on Cost Savings and Clinical Outcomes at an Academic Medical Center.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Clinical reasoning for performance of transesophageal echocardiography in veterans withAntimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Outpatient parenteral antimicrobial therapy in Germany: a prospective cohort study protocol.BMJ open · 2022Article
- Outpatient parenteral antimicrobial therapy (OPAT) service is associated with inpatient-bed cost savings.The British journal of cardiology · 2021Article
- A narrative review of the interpretation of guidelines for the treatment of infective endocarditis.Annals of translational medicine · 2020Review
- Adverse Events and Healthcare Utilization Associated With Outpatient Parenteral Antimicrobial Therapy Among Older Versus Younger Adults.Open forum infectious diseases · 2020Article
- Clinical outcomes of teicoplanin use in the OPAT setting.International journal of antimicrobial agents · 2020Article
- Risk factors for readmission in patients discharged with outpatient parenteral antimicrobial therapy: a retrospective cohort study.BMC pharmacology & toxicology · 2018Article
- Incidence and risk factors for healthcare utilisation among patients discharged on outpatient parenteral antimicrobial therapy.Epidemiology and infection · 2018Article
- Managing infective endocarditis in the elderly: new issues for an old disease.Clinical interventions in aging · 2016Review
- Multidrug-resistant bacterial infections after liver transplantation: an ever-growing challenge.World journal of gastroenterology · 2014Review
- Prediction model for 30-day hospital readmissions among patients discharged receiving outpatient parenteral antibiotic therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Article
- Managing an outpatient parenteral antibiotic therapy team: challenges and solutions.Therapeutics and clinical risk management · 2014Review
- Outpatient parenteral antimicrobial therapy (OPAT) and the general physician.Clinical medicine (London, England) · 2013Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo identify risk factors for failure of outpatient antibiotic therapy (OPAT) in infective endocarditis (IE). PATIENTS AND
methodsWe identified IE cases managed at a single centre over 12 years from a prospectively maintained database. 'OPAT failure' was defined as unplanned readmission or antibiotic switch due to adverse drug reaction or antibiotic resistance. We analysed patient and disease-related risk factors for OPAT failure by univariate and multivariate logistic regression. We also retrospectively collected follow-up data on adverse disease outcome (defined as IE-related death or relapse) and performed Kaplan-Meier survival analysis up to 36 months following OPAT.
resultsWe identified 80 episodes of OPAT in IE. Failure occurred in 25/80 episodes (31.3%). On multivariate analysis, cardiac or renal failure [pooled OR 7.39 (95% CI 1.84-29.66), P=0.005] and teicoplanin therapy [OR 8.69 (95% CI 2.01-37.47), P=0.004] were independently associated with increased OPAT failure. OPAT failure with teicoplanin occurred despite therapeutic plasma levels. OPAT failure predicted adverse disease outcome up to 36 months (P=0.016 log-rank test).
conclusionsThese data caution against selecting patients with endocarditis for OPAT in the presence of cardiac or renal failure and suggest teicoplanin therapy may be associated with suboptimal OPAT outcomes. Alternative regimens to teicoplanin in the OPAT setting should be further investigated.
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