Evidence map›Paper›PMID 23475593›Full record

ArticleMolecular biotechnology2013

A comparative study of nitrilases identified by genome mining.

Ondřej Kaplan, Alicja B Veselá, Alena Petříčková, Fabrizia Pasquarelli, Martina Pičmanová, Anna Rinágelová, Tek Chand Bhalla, Miroslav Pátek, Ludmila Martínková

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Molecular biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Genetic and Functional Diversity of Nitrilases in Agaricomycotina.International journal of molecular sciences · 2019
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Ondřej KaplanInstitute of Microbiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220 Prague, Czech Republic.
Alicja B Veselá
Alena Petříčková
Fabrizia Pasquarelli
Martina Pičmanová
Anna Rinágelová
Tek Chand Bhalla
Miroslav Pátek
Ludmila Martínková
Czech Academy of Sciences · CZCzech Academy of Sciences, Institute of Microbiology · CZCharles University · CZHimachal Pradesh University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Escherichia coli strains expressing different nitrilases transformed nitriles or KCN. Six nitrilases (from Aspergillus niger (2), A. oryzae, Neurospora crassa, Arthroderma benhamiae, and Nectria haematococca) were arylacetonitrilases, two enzymes (from A. niger and Penicillium chrysogenum) were cyanide hydratases and the others (from P. chrysogenum, P. marneffei, Gibberella moniliformis, Meyerozyma guilliermondi, Rhodococcus rhodochrous, and R. ruber) preferred (hetero)aromatic nitriles as substrates. Promising nitrilases for the transformation of industrially important substrates were found: the nitrilase from R. ruber for 3-cyanopyridine, 4-cyanopyridine and bromoxynil, the nitrilases from N. crassa and A. niger for (R,S)-mandelonitrile, and the cyanide hydratase from A. niger for KCN and 2-cyanopyridine.

Indexed as

Genome, FungalAminohydrolasesEscherichia coliFungal ProteinsFungiGenomicsHydro-LyasesRecombinant ProteinsSequence AlignmentSequence Analysis, DNASequence Homology, Amino AcidSubstrate SpecificityAminohydrolasescyanide hydrataseFungal ProteinsHydro-LyasesnitrilaseRecombinant Proteins

Identifiers

PMID23475593
OpenAlexW1977625441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.