ArticleJournal of leukocyte biology2013
Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish.
Article in Journal of leukocyte biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Stat3 Regulates Developmental Hematopoiesis and Impacts Myeloid Cell Function via Canonical and Non-Canonical Modalities.Journal of innate immunity · 2024Article
- Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish.Nature communications · 2023Article
- Oxoeicosanoid signaling mediates early antimicrobial defense in zebrafish.Cell reports · 2023Article
- Application of transgenic zebrafish for investigating inflammatory responses to nanomaterials: Recommendations for new users.F1000Research · 2023Review
- Neutrophil reverse migration.Journal of inflammation (London, England) · 2022Review
- Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation.Journal of leukocyte biology · 2022Article
- Real-time imaging of inflammation and its resolution: It's apparent because it's transparent.Immunological reviews · 2022Review
- Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.Cell host & microbe · 2021Article
- Zebrafish Embryo Infection Model to InvestigateFrontiers in cellular and infection microbiology · 2021Review
- Molecular Insights Into Neutrophil Biology From the Zebrafish Perspective: Lessons From CD18 Deficiency.Frontiers in immunology · 2021Article
- Gram-Negative BacteriaFrontiers in pharmacology · 2021Article
- Transcriptome sequencing supports a conservation of macrophage polarization in fish.Scientific reports · 2020Article
- Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils.The Journal of biological chemistry · 2020Article
- Zebrafish Bacterial Infection Assay to Study Host-Pathogen Interactions.Bio-protocol · 2020Article
- Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs.Frontiers in cell and developmental biology · 2020Review
- Live Imaging of Heart Injury in Larval Zebrafish Reveals a Multi-Stage Model of Neutrophil and Macrophage Migration.Frontiers in cell and developmental biology · 2020Article
- Chemokine Receptors and Phagocyte Biology in Zebrafish.Frontiers in immunology · 2020Review
- Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish.Nature communications · 2019Article
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Authors and funding
6 authors.
Funding
Abstract
Neutrophils are the first line of defense against tissue damage and are rapidly mobilized to sites of bacterial infection. However, the signals that regulate neutrophil recruitment are not well defined. Here, using photolabel-enabled fate mapping in zebrafish larvae, we show that localized otic infection with Pseudomonas aeruginosa induces systemic activation and mobilization of neutrophils from the CHT through Cxcr2 signaling. We have cloned the zebrafish Cxcr1 and Cxcr2 receptors and show that Cxcr2 functions as a Cxcl8 receptor in live zebrafish. With the use of morpholino-mediated depletion, we show that infection-induced neutrophil mobilization from the CHT is mediated by Cxcr2 but not Cxcr1. By contrast, Cxcr2 depletion does not affect neutrophil recruitment to the chemoattractant LTB4. Taken together, our findings identify Cxcl8-Cxcr2 signaling as an infection-induced long-range cue that mediates neutrophil motility and mobilization from hematopoietic tissues, positioning Cxcr2 as a critical pathway that mediates infection-induced systemic activation of neutrophils.
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Registered trials
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