ArticleJournal of experimental zoology. Part B, Molecular and developmental evolution2013
Identification of a novel metalloproteinase and its role in juvenile development of the tobacco hornworm, Manduca sexta (Linnaeus).
Article in Journal of experimental zoology. Part B, Molecular and developmental evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- The Developmental Transcriptome ofG3 (Bethesda, Md.) · 2020Article
- Effects of high-fat diet on feeding and performance in the tobacco hornworm, Manduca sexta.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2019Article
- The effect of within-instar development on tracheal diameter and hypoxia-inducible factors α and β in the tobacco hornworm, Manduca sexta.Journal of insect physiology · 2018Article
- Identification and initial characterization of matrix metalloproteinases in the yellow fever mosquito, Aedes aegypti.Insect molecular biology · 2017Article
- Immune Defense Varies within an Instar in the Tobacco Hornworm, Manduca sexta.Physiological and biochemical zoology : PBZArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Matrix metalloproteinases (MMPs) are a class of zinc-dependent endopeptidases that are highly conserved across numerous taxa, from bacteria to humans. Recently, MMPs have been identified in several insect species and are hypothesized to function in immunity and development. In this study, we identify a putative MMP and correlate its proteolytic activity and gene and protein expression in the tracheae with developmental stage. Ms-MMP gene expression increases 10-fold during molting, which is accompanied by an increase in both protein expression and gelatinolytic activity. To directly test the hypothesis that Ms-MMP plays a critical role in juvenile development of Manduca sexta, we injected a broad-spectrum MMP inhibitor and recorded its effects on growth and development. Inhibition of MMPs caused a delay in juvenile development and decreased growth rates. Understanding the function of MMPs will help us better understand molting and control of body size in insects. Furthermore, elucidating functions for MMPs in lower taxa may yield critical information about the evolution of the numerous MMPs found in vertebrates.
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